Promising nanogels loaded with usnic acid for oral ulcer treatment: Development, characterization, and in vivo evaluation in rabbits

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dc.authorid0000-0003-2143-5268
dc.contributor.authorCoşkunmeriç, Nesrin
dc.contributor.authorÜstündağ Okur, Neslihan
dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorAyla, Şule
dc.contributor.authorYoltaş, Ayşegül
dc.contributor.authorKaravana, Sinem Yaprak
dc.date.accessioned2021-10-19T12:27:04Z
dc.date.available2021-10-19T12:27:04Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThis study aimed to present an effective formulation targeting oral ulcers that will remain in the application site for a longer period, reducing the frequency of administration. As a candidate formulation, usnic acid (UA) was loaded into the optimum nanogels. The characterization studies included physical, rheological, and bioadhesive properties as well as in vitro release and ex vivo studies. The rheological results revealed that the nanogels present pseudoplastic flow behavior. In vitro drug release showed a prolonged pattern. In further, the chosen UA nanogels showed very low percentages of penetration and permeation. F13, which showed the highest release, suitable bioadhesive properties (0.475 +/- 0.033 N/cm(2)) and eligible particle size (250.22 +/- 4.11 nm), PDI (0.089 +/- 0.052), and zeta potential (20.56 +/- 0.330 mV) values were chosen for in vivo experiments. The selected UA nanogels showed effective antimicrobial activity against Bacillus Cereus and great in vivo wound healing properties. The results indicated that suitable UA nanogels with desired properties could be prepared. The therapeutic potential of the nanogels for oral ulcers was assessed using an animal model and the histopathological findings suggested that the optimized formulation is a good choice for oral ulcer treatment. Nonetheless, further research is recommended to support its efficacy by applying pharmacodynamic and pharmacokinetic studies in human individuals.
dc.identifier.citationCoşkunmeriç, N., Üstündağ Okur, N., Okur, M. E., Ayla, Ş., Yoltaş, A. ve Karavana, S. Y. (2021). Promising nanogels loaded with usnic acid for oral ulcer treatment: Development, characterization, and in vivo evaluation in rabbits. Pharmaceutical Development and Technology, 26(4), 431-443. https://dx.doi.org/10.1080/10837450.2021.1885441
dc.identifier.doi10.1080/10837450.2021.1885441
dc.identifier.endpage443
dc.identifier.issn1083-7450
dc.identifier.issn1097-9867
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage431
dc.identifier.urihttps://dx.doi.org/10.1080/10837450.2021.1885441
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8471
dc.identifier.volume26
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofPharmaceutical Development and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectOral Ulcer
dc.subjectBuccal Formulations
dc.subjectNanogel
dc.subjectOral Wound Healing
dc.subjectRabbit
dc.subjectUsnic Acid
dc.titlePromising nanogels loaded with usnic acid for oral ulcer treatment: Development, characterization, and in vivo evaluation in rabbits
dc.typeArticle

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