The role of serum interleukin-6 and C-reactive protein levels for differentiating aetiology of neonatal sepsis

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dc.contributor.authorÇelik, İstemi Han
dc.contributor.authorDemirel, Gamze
dc.contributor.authorUraş, Nurdan
dc.contributor.authorO?uz, Şerife Suna
dc.contributor.authorErdeve, Ömer
dc.contributor.authorDílmen, U?ur
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:32Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:32Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractIntroduction: In our clinical practice, we observed high interleukin-6 (IL-6) levels in gram-negative sepsis. Objective: To investigate the relationship between IL-6 and C-reactive protein (CRP) levels and early determination of neonatal sepsis of gram-negative or gram-positive aetiology. Population and Methods: White blood cell count, IL-6 and CRP levels were compared among different groups. Results: Gram-negative, gram-positive and fungal infection groups consisted of 73, 82 and 15 patients, respectively. The optimal cut-off levels of IL-6 between gram-negative and gram-positive fungal infection groups were 202 and 57 pg/ ml. The fungal infection group had higher CRP levels than gram-negative and positive infection groups. Conclusions: To our knowledge, this is the largest reported study aiming at determining of IL-6 cut-off levels to differentiate neonatal sepsis aetiology. Gram-negative microorganisms led to 10 fold higher IL-6 production. The evaluation of IL-6 and CRP is useful to diagnose and also differentiate neonatal sepsis aetiology.
dc.identifier.citationÇelik, İ. H., Demirel, G., Uraş, N., O?uz, Ş. S., Erdeve, Ö., ve Dilmen, U. (2015). The role of serum interleukin-6 and C-reactive protein levels for differentiating aetiology of neonatal sepsis. Archivos Argentinos de Pediatria, 113(6), 534-537. https://dx.doi.org/10.5546/aap.2015.eng.534
dc.identifier.doi10.5546/aap.2015.eng.534
dc.identifier.endpage537
dc.identifier.issn0325-0075
dc.identifier.issue6
dc.identifier.scopusqualityQ3
dc.identifier.startpage534
dc.identifier.urihttps://hdl.handle.net/20.500.12511/833
dc.identifier.urihttps://dx.doi.org/10.5546/aap.2015.eng.534
dc.identifier.volume113
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSociedad Argentina de Pediatria
dc.relation.ispartofArchivos Argentinos de Pediatriaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNewborn
dc.subjectSepsis
dc.subjectInterleukin-6
dc.subjectC-reactive Protein
dc.subjectGramnegative Infections
dc.subjectFungal Disease
dc.titleThe role of serum interleukin-6 and C-reactive protein levels for differentiating aetiology of neonatal sepsis
dc.typeArticle

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