Are there consistent abnormalities in event-related EEG oscillations in patients with Alzheimer's disease compared to other diseases belonging to dementia?

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dc.authorid0000-0002-0860-0524
dc.authorid0000-0002-7555-3801
dc.authorid0000-0003-4292-5717
dc.authorid0000-0002-7715-3035
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorAktürk, Tuba
dc.contributor.authorArakaki, Xianghong
dc.contributor.authorBonanni, Laura
dc.contributor.authorDel Percio, Claudio
dc.contributor.authorEdelmayer, Rebecca
dc.contributor.authorFarina, Francesca
dc.contributor.authorFerri, Raffaele
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorKumar, Sanjeev
dc.contributor.authorLizio, Roberta
dc.contributor.authorLopez, Susanna
dc.contributor.authorMurphy, Brian
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorRandall, Fiona
dc.contributor.authorSack, Alexander T.
dc.contributor.authorStocchi, Fabrizio
dc.contributor.authorYener, Görsev
dc.contributor.authorYıldırım, Ebru
dc.contributor.authorBabiloni, Claudio
dc.date.accessioned2022-12-19T10:12:02Z
dc.date.available2022-12-19T10:12:02Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, İMÜ Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractCerebrospinal and structural-molecular neuroimaging in-vivo biomarkers are recommended for diagnostic purposes in Alzheimer’s disease (AD) and other dementias; however, they do not explain the effects of AD neuropathology on neurophysiological mechanisms underpinning cognitive processes. Here, an Expert Panel from the Electrophysiology Professional Interest Area of the Alzheimer’s Association reviewed the field literature and reached consensus on the event-related electroencephalographic oscillations (EROs) that show consistent abnormalities in patients with significant cognitive deficits due to Alzheimer’s, Parkinson’s (PD), Lewy body (LBD), and cerebrovascular diseases. Converging evidence from oddball paradigms showed that, as compared to cognitively unimpaired (CU) older adults, AD patients had lower amplitude in widespread delta (>4 Hz) and theta (4–7 Hz) phase-locked EROs as a function of disease severity. Similar effects were also observed in PD, LBD, and/or cerebrovascular cognitive impairment patients. Non-phase-locked alpha (8–12 Hz) and beta (13–30 Hz) oscillations were abnormally reduced (event-related desynchronization, ERD) in AD patients relative to CU. However, studies on patients with other dementias remain lacking. Delta and theta phase-locked EROs during oddball tasks may be useful neurophysiological biomarkers of cognitive systems at work in heuristic and intervention clinical trials performed in AD patients, but more research is needed regarding their potential role for other dementias.
dc.description.sponsorshipEuropean Committee (H2020-EU.1.3.1.H2020-MSCA-ITN-ETN-2016 project)en_US
dc.identifier.citationGüntekin, B., Aktürk, T., Arakaki, X., Bonanni, L., Del Percio, C., Edelmayer, R. ... Babiloni, C. (2022). Are there consistent abnormalities in event-related EEG oscillations in patients with Alzheimer's disease compared to other diseases belonging to dementia? Psychophysiology, 59(5). https://doi.org/10.1111/psyp.13934
dc.identifier.doi10.1111/psyp.13934
dc.identifier.issn0048-5772
dc.identifier.issn1469-8986
dc.identifier.issue5
dc.identifier.pmid34460957
dc.identifier.scopus2-s2.0-85113871269
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/psyp.13934
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10145
dc.identifier.volume59
dc.identifier.wos000691021400001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüntekin, Bahar
dc.institutionauthorAktürk, Tuba
dc.institutionauthorHanoğlu, Lütfü
dc.institutionauthorYıldırım, Ebru
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofPsychophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlzheimer’s Disease Mild Cognitive Impairment (ADMCI)
dc.subjectAlzheimer’s Disease (AD)
dc.subjectEvent- Related Desynchronization
dc.subjectEvent- Related Oscillations (EROs)
dc.subjectEvent- Related Potentials (ERPs)
dc.subjectEvent- Related Synchronization
dc.subjectLewy Body Dementia (LBD)
dc.subjectParkinson’s Disease (PD)
dc.subjectVascular Cognitive Impairment (VCI)
dc.titleAre there consistent abnormalities in event-related EEG oscillations in patients with Alzheimer's disease compared to other diseases belonging to dementia?
dc.typeArticle

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