Methylnitrosourea, dimethylbenzanthracene and benzoapyrene differentially affect redox pathways, apoptosis and immunity in zebrafish

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dc.authorid0000-0003-0804-1475
dc.contributor.authorEğimezer, G.
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorAteş, Perihan Seda
dc.contributor.authorÜnal, İsmail
dc.contributor.authorÜstündağ, F. D.
dc.contributor.authorAlturfan, Ahmet Ata
dc.contributor.authorEmekli-Alturfan, Ebru
dc.contributor.authorAdil Altınöz, Meriç
dc.contributor.authorElmacı, İlhan
dc.date.accessioned2020-07-13T09:46:24Z
dc.date.available2020-07-13T09:46:24Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractCancer continues to be a major cause of mortality globally. Zebrafish present suitable models for studying the mechanisms of genotoxic carcinogens. The aim of this study was to investigate the interaction between oxidant-antioxidant status, apoptosis and immunity in zebrafish that were exposed to three different genotoxic carcinogens methylnitrosourea, dimethylbenzanthracene, benzoapyrene and methylnitrosourea + dimethylbenzanthracene starting from early embryogenesis for 30 days. Lipid peroxidation, nitric oxide levels, superoxide dismutase and glutathione-S-transferase activities and mRNA levels of apoptosis genes p53, bax, casp3a, casp2 and immunity genes fas, tnf alpha and ifn gamma 1 were evaluated. The disruption of the oxidant-antioxidant balance accompanied by altered expressions of apoptotic and immunity related genes were observed in different levels according to the carcinogen applied. Noteworthy, ifn gamma expressions decreased in all carcinogen-exposed groups. Our results will provide basic data for further carcinogenesis research in zebrafish models.
dc.identifier.citationEğimezer, G., Üstündağ, Ü. V., Ateş, P. S., Ünal, İ., Üstündağ, F. D., Alturfan, A. A. ... Elmacı, İ. (2020). Methylnitrosourea, dimethylbenzanthracene and benzoapyrene differentially affect redox pathways, apoptosis and immunity in zebrafish. Human and Experimental Toxicology, 39(7), 920-929. https://dx.doi.org/10.1177/0960327120905961
dc.identifier.doi10.1177/0960327120905961
dc.identifier.endpage929
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue7
dc.identifier.scopusqualityQ2
dc.identifier.startpage920
dc.identifier.urihttps://dx.doi.org/10.1177/0960327120905961
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5466
dc.identifier.volume39
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSAGE Publications Ltd
dc.relation.ispartofHuman and Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectMethylnitrosourea
dc.subjectDimethylbenzanthracene
dc.subjectBenzoapyrene
dc.subjectAntioxidant
dc.subjectApoptosis
dc.subjectImmunity
dc.subjectZebrafish
dc.titleMethylnitrosourea, dimethylbenzanthracene and benzoapyrene differentially affect redox pathways, apoptosis and immunity in zebrafish
dc.typeArticle

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