Association and prognostic significance of the functional-1562C/T polymorphism in the promoter region of MMP-9 in Turkish patients with gastric cancer

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dc.contributor.authorAvcı, Nilüfer
dc.contributor.authorTüre, Mehmet
dc.contributor.authorDeligönül, Adem
dc.contributor.authorÇubukçu, Erdem
dc.contributor.authorÖlmez, Ömer Fatih
dc.contributor.authorŞahintürk, Serdar
dc.contributor.authorTopak, Ali
dc.contributor.authorKurt, Ender
dc.contributor.authorEvrensel, Türkan
dc.contributor.authorŞahin, Ahmet Bilgehan
dc.contributor.authorYakut, Tahsin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:22Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:22Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000360385400050
dc.descriptionPubMed ID: 26156886
dc.description.abstractMatrix metalloproteinases (MMPs) are a group of zinc-dependent peptidases that participate in matrix turnover in solid malignancies. The aim of this study was twofold. First, we sought to investigate under a case-control design the association between the functional -1562C/T polymorphism in the promoter region of MMP-9 and gastric cancer (GC) in a Turkish sample. Second, we examined its prognostic significance in GC patients. A total of 144 subjects were enrolled in the case-control study (79 GC cases and 65 controls). Overall survival (OS) and progression-free survival (PFS) served as the main outcome measures in the longitudinal study. The MMP-9 -1562C/T polymorphism was genotyped using a polymerase chain reaction-restriction fragment length polymorphism method. The odds ratio (OR) of GC for the CC genotype relative to the CT+TT genotypes was not significant (OR = 0.89, 95 % confidence interval [CI] = 0.44-1.82, P = 0.75). These results did not change after allowance for age and sex in multivariable regression analysis (OR = 0.81, 95 % CI = 0.40-1.94, P = 0.84). When the MMP-9 -1562C/T polymorphism was analyzed among GC patients in relation to OS and PFS, we found no significant differences between subjects with the CC and CT+TT genotypes. In conclusion, the results of our study did not point toward a major role of the MMP-9 -1562C/T polymorphism in the pathogenesis and clinical course of GC in Turkish subjects.
dc.identifier.citationAvcı, N., Türe, M., Deligönül, A., Çubukçu, E., Ölmez, Ö. F., Şahintürk, S. ... Yakut, T. (2015). Association and prognostic significance of the functional-1562C/T polymorphism in the promoter region of MMP-9 in Turkish patients with gastric cancer. Pathology & Oncology Reserach, 21(4), 1243-1247. https://dx.doi.org/10.1007/s12253-015-9950-7
dc.identifier.doi10.1007/s12253-015-9950-7
dc.identifier.endpage1247
dc.identifier.issn1219-4956
dc.identifier.issn1532-2807
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage1243
dc.identifier.urihttps://dx.doi.org/10.1007/s12253-015-9950-7
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3630
dc.identifier.volume21
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPathology & Oncology Reserachen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectGastric Cancer
dc.subjectMatrix Metalloproteinases
dc.subjectPolymorphism
dc.subjectAssociation Study
dc.subjectPrognosis
dc.titleAssociation and prognostic significance of the functional-1562C/T polymorphism in the promoter region of MMP-9 in Turkish patients with gastric cancer
dc.typeArticle

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