Impact of GLP-1 analogue on oxidative damage and hepatic regeneration in experimental 70% hepatectomy model

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dc.authorid0000-0003-0428-2511
dc.contributor.authorBattal, Muharrem
dc.contributor.authorÇitgez, Bülent
dc.contributor.authorKartal, Abdülcabbar
dc.contributor.authorKemik, Ahu
dc.contributor.authorYıldırım, Pınar
dc.contributor.authorÖzdenkaya, Yaşar
dc.contributor.authorYılmaz, Ahmet
dc.contributor.authorKaratepe, O?uzhan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:11Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:11Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.descriptionWOS: 000352115800002
dc.descriptionPubMed ID: 25916043
dc.description.abstractBackground/Aims: The purpose of our study is researching into impact of glucagon like peptide 1 (GLP 1) analogue on liver regeneration after major hepatectomy. Methodology: 24 wistar albino rats were consecutively divided into 3 groups. Group 1: Control (sham) group day 14 (n=8), Group 2: Liver resection group day 14 (n=8); 70% Liver resection was performed, Group 3: Study group day 14 (n=8); Subsequent to performing 70% liver resection, GLP-1 analogue was administered 2 times a day (10 mu gr/70 kg x 2 times). After 14 day, rats were sacrificed. Oxidative stress and antioxidant enzymes and mitochondrial permeability transition, cytochrome-c, Bax, Bcl-2, caspase-3, caspase-8 and caspase-3 activity were examined. Results: 70% Liver resection induced oxidative stress of liver tissue was ameliorated by GLP 1 induction. Administration of GLP increased Bcl-2 expression. Decreased expression of cytochrome-c was accompanied by a decrease caspase-3, caspase-8, and Bax expression and caspase-3 activity. Conclusions: Glp 1 induction plays a regenerative role in the major hepatectomy. This effect is dependent on modulation of the antiapoptotic and antioxidative pathways by GLP 1 expression.
dc.identifier.citationBattal, M., Çitgez, B., Kartal, A., Kemik, A., Yıldırım, P., Özdenkaya, Y. ... Karatepe, O. (2015). Impact of GLP-1 analogue on oxidative damage and hepatic regeneration in experimental 70% hepatectomy model. Hepato-Gastroenterology, 62(138), 257-260. https://dx.doi.org/10.5754/hge14958
dc.identifier.doi10.5754/hge14958
dc.identifier.endpage260
dc.identifier.issn0172-6390
dc.identifier.issue138
dc.identifier.scopusqualityQ2
dc.identifier.startpage257
dc.identifier.urihttps://dx.doi.org/10.5754/hge14958
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2611
dc.identifier.volume62
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherUpdate Medical Publishing
dc.relation.ispartofHepato-Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGLP-1
dc.subjectLiver Resection
dc.subjectOxidative Damage
dc.subjectRegeneration
dc.titleImpact of GLP-1 analogue on oxidative damage and hepatic regeneration in experimental 70% hepatectomy model
dc.typeArticle

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