The association between HbA1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic persons

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dc.authorid0000-0002-9704-6173
dc.authorid0000-0003-4292-5717
dc.authorid0000-0002-1079-8832
dc.authorid0000-0001-6494-8923
dc.contributor.authorYulu?, Burak
dc.contributor.authorSaatçi, Özlem
dc.contributor.authorIşıklar, Aysun
dc.contributor.authorHano?lu, Lütfü
dc.contributor.authorKılıç, Ülkan
dc.contributor.authorOzansoy, Mehmet
dc.contributor.authorÇankaya, Şeyda
dc.contributor.authorÇankaya, Barış
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned2020-04-21T06:37:29Z
dc.date.available2020-04-21T06:37:29Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractBackground and Aim: Recent data have shown that olfactory dysfunction is strongly related to Alzheimer's Disease (AD) that is often preceded by olfactory deficits suggesting that olfactory dysfunction might represent an early indicator of future cognitive in prediabetes.Methods: We have applied to a group of normal (n=15), prediabetic (n=16) and type 2 diabetic outpatients (n=15) olfactory testing, 1.5-T MRI scanner and detailed cognitive evaluation including the standard Mini-Mental State Examination (MMSE) form, Short Blessed Test (SBT), Letter Fluency Test (LFT) and the category fluency test with animal, Fruit and Vegetable Naming (CFT).Results: We have shown that Odour Threshold (OT), Discrimination (OD), and Identification (OI) scores and most cognitive test results were significantly different in the prediabetes and diabetes group compared to those in the control group. OD and OT were significantly different between the prediabetes and diabetes group, although the cognitive test results were only significantly different in the pre-diabetes and diabetes group compared to those in the control group. In evaluating the association between OI, OT, OD scores and specific cognitive tests, we have found, that impaired olfactory identification was the only parameter that correlated significantly with the SBT both in the pre-diabetes and diabetes group. Although spot glucose values were only correlated with OT, HbA1c levels were correlated with OT, OD, and OI, as well as results of the letter fluency test suggesting that HbA1c levels rather than the spot glucose values play a critical role in specific cognitive dysfunction.Conclusion: To the best of our knowledge, this is the first prospective study to demonstrate a strong association between olfactory dysfunction and specific memory impairment in a population with pre-diabetes and diabetes suggesting that impaired olfactory identification might play an important role as a specific predictor of memory decline.
dc.identifier.citationYulu?, B., Saatçi, Ö., Işıklar, A., Hano?lu, L., Kılıç, Ü., Ozansoy, M. ... Kılıç, E. (2020). The association between HbA1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic persons. Endocrine Metabolic & Immune Disorders-Drug Targets, 20(2), 198-212. https://dx.doi.org/10.2174/1871530319666190614121738
dc.identifier.doi10.2174/1871530319666190614121738
dc.identifier.endpage212
dc.identifier.issn1871-5303
dc.identifier.issn2212-3873
dc.identifier.issue2
dc.identifier.scopusqualityQ3
dc.identifier.startpage198
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5182
dc.identifier.urihttps://dx.doi.org/10.2174/1871530319666190614121738
dc.identifier.volume20
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofEndocrine Metabolic & Immune Disorders-Drug Targetsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOlfaction
dc.subjectCognition
dc.subjectPrediabetes
dc.subjectDiabetes
dc.subjectOlfactory Memory
dc.subjectMemory Dysfunction
dc.titleThe association between HbA1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic persons
dc.typeArticle

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