Pretreatment platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio as a predictor of pathological complete response to neoadjuvant chemotherapy in patients with breast cancer: Single center experience from Turkey

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dc.authorid0000-0003-2715-4002
dc.authorid0000-0002-0443-6966
dc.authorid0000-0001-7934-7039
dc.authorid0000-0002-9452-9276
dc.authorid0000-0003-0128-6947
dc.contributor.authorAçıkgöz, Özgür
dc.contributor.authorYıldız, Anıl
dc.contributor.authorBilici, Ahmet
dc.contributor.authorÖlmez, Ömer Fatih
dc.contributor.authorBasım, Pelin
dc.contributor.authorÇakır, Aslı
dc.date.accessioned2022-11-04T07:55:30Z
dc.date.available2022-11-04T07:55:30Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractThe aim of this study was to investigate the predictive value of PLR and NLR as an indicator of pathological complete response (pCR) in patients with breast cancer after NACT. One hundred thirty-nine patients with early or LABC and candidates to NACT were retrospectively analyzed. The prognostic significance of PLR and NLR was analyzed. In addition, predictive indicators of pCR to NACT were also evaluated. pCR was obtained in 48.9% of patients. Significant difference was detected between pCR and PLR, tumor grade, clinical lymph node status and molecular subgroup. The higher rate of pCR was significantly achieved for patients with PLRlow (<181.7) compared with those with PLRhigh (>181.7) (68.6% vs. 33.4%; P < 0.001). PLR, tumor grade and pCR to NACT for disease-free survival (DFS), and PLR, NLR, tumor grade and pCR to NACT for overall survival were detected to be prognostic factors by univariate analysis. On the other hand, a logistic regression analysis indicated that PLR and NLR were found to be an independent factors for predicting pCR to NACT (P < 0.001; OR, 0.07; 95% CI, 0.02-0.25 and P = 0.016; OR, 4.66; 95% CI, 1.33-16.2, respectively), as were molecular subtypes (P = 0.001; OR, 0.23; 95% CI, 0.09-0.56). Our results showed that PLRlow and NLRlow before NACT are readily feasible and simple and also inexpensive biomarkers predicting pCR to NACT for patients with LABC.
dc.identifier.citationAçıkgöz, Ö., Yıldız, A., Bilici, A., Ölmez, Ö. F., Basım, P. ve Çakır, A. (2022). Pretreatment platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio as a predictor of pathological complete response to neoadjuvant chemotherapy in patients with breast cancer: Single center experience from Turkey. Anti-Cancer Drugs, 33(10), 1150-1155. https://doi.org/10.1097/CAD.0000000000001389
dc.identifier.doi10.1097/CAD.0000000000001389
dc.identifier.endpage1155
dc.identifier.issn0959-4973
dc.identifier.issn1473-5741
dc.identifier.issue10
dc.identifier.pmid36206103
dc.identifier.scopus2-s2.0-85140272684
dc.identifier.scopusqualityQ3
dc.identifier.startpage1150
dc.identifier.trdizinid36206103
dc.identifier.urihttps://doi.org/10.1097/CAD.0000000000001389
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9920
dc.identifier.volume33
dc.identifier.wos000869257200019en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAçıkgöz, Özgür
dc.institutionauthorYıldız, Anıl
dc.institutionauthorBilici, Ahmet
dc.institutionauthorÖlmez, Ömer Fatih
dc.institutionauthorBasım, Pelin
dc.institutionauthorÇakır, Aslı
dc.language.isoen
dc.publisherLippincott Williams and Wilkins
dc.relation.ispartofAnti-Cancer Drugsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBreast Cancer
dc.subjectNeoadjuvant Chemotherapy
dc.subjectNeutrophil-Lymphocyte Ratio
dc.subjectPathological Complete Response
dc.subjectPlatelet-Lymphocyte Ratio
dc.titlePretreatment platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio as a predictor of pathological complete response to neoadjuvant chemotherapy in patients with breast cancer: Single center experience from Turkey
dc.typeArticle

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