Abnormalities in auditory and visual cognitive processes are differentiated with theta responses in patients with Parkinson's disease with and without dementia

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dc.authorid0000-0002-0860-0524
dc.authorid0000-0002-7555-3801
dc.authorid0000-0002-7715-3035
dc.authorid0000-0001-7566-1063
dc.authorid0000-0003-4292-5717
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorAktürk, Tuba
dc.contributor.authorYıldırım, Ebru
dc.contributor.authorHelvacı Yılmaz, Nesrin
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorYener, Görsev
dc.date.accessioned2020-07-07T12:39:04Z
dc.date.available2020-07-07T12:39:04Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, İMÜ Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractThe research on the abnormalities of event-related oscillations in Parkinson's disease (PD) was mostly studied with cognitively normal patients. The present study aims to show the adverse effects of cognitive decline in PD patients via the EEG-Brain Oscillations approach by comparing the electrophysiological responses in two modalities, i.e. auditory, and visual in which PD group show deficit. We conducted a study in which we analyzed event-related theta power and phase-locking during auditory and visual oddball paradigm. Cognitively normal PD (PDCN) patients (N = 15), PD with mild cognitive impairment (PDMCI) patients (N = 22), PD dementia (PDD) patients (N = 11) and healthy controls (HC) (N = 17) were included in the study. Neuropsychological assessments were applied to all participants. There was a gradual decrease in scores of neuropsychological tests (HC, PDCN, PDMCI, PDD, respectively). Most of the neuropsychological test scores of the participants were highly correlated with the theta power and theta phase locking values, especially over frontal-central areas. HC had higher theta phase-locking and power in comparison to PDMCI and PDD. The differentiation between HC and PDCN was specific to frontal-central areas. Theta power and theta phase-locking were decreased overall locations in PDMCI and PDD both during visual and auditory oddball paradigms compared with PDCN. The results indicate that theta responses in PD patients decreased gradually as the cognitive decline increased. We can conclude that complex abnormalities in their neurotransmitter and neuronal signal systems that occur with the progression of the disease could be responsible for these results.
dc.identifier.citationGüntekin, B., Aktürk, T., Yıldırım, E., Helvacı Yılmaz, N., Hanoğlu, L. ve Yener, G. (2020). Abnormalities in auditory and visual cognitive processes are differentiated with theta responses in patients with Parkinson's disease with and without dementia. International Journal of Psychophysiology, 153, 65-79. https://dx.doi.org/10.1016/j.ijpsycho.2020.04.016
dc.identifier.doi10.1016/j.ijpsycho.2020.04.016
dc.identifier.endpage79
dc.identifier.issn0167-8760
dc.identifier.issn1872-7697
dc.identifier.scopusqualityQ2
dc.identifier.startpage65
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijpsycho.2020.04.016
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5412
dc.identifier.volume153
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Psychophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/214S111
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectEEG
dc.subjectParkinson's Disease
dc.subjectDementia
dc.subjectTheta
dc.subjectEvent-Related Oscillations
dc.titleAbnormalities in auditory and visual cognitive processes are differentiated with theta responses in patients with Parkinson's disease with and without dementia
dc.typeArticle

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