An efficient approach to access 2,5-disubstituted 1,3,4-oxadiazoles by oxidation of 2-arenoxybenzaldehyde N-acyl hydrazones with molecular iodine
| dc.authorid | 0000-0002-1423-0435 | |
| dc.contributor.author | Başpınar Küçük, Hatice | |
| dc.contributor.author | Alhonaish, Anoud | |
| dc.contributor.author | Yıldız, Tülay | |
| dc.contributor.author | Güzel, Mustafa | |
| dc.date.accessioned | 2022-07-21T07:27:44Z | |
| dc.date.available | 2022-07-21T07:27:44Z | |
| dc.date.issued | 2022 | |
| dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü | |
| dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı | |
| dc.description.abstract | An oxidative cyclization of 2-arenoxybenzaldehyde N-acyl hydrazones 3 a-o was employed to synthesize new 2,5-disubstituted 1,3,4-oxadiazole compounds 4 a-d, 4 f-i, 4 k-n. This method involves oxidative cyclization of 2-arenoxybenzaldehyde N-acyl hydrazones 3 a-o with molecular iodine mediated catalysis in which potassium carbonate served as a base. Characterization of all the synthesized novel compounds involved, proton and carbon NMR, mass spectrometry, and CHN elemental analysis. The synthesis of novel 2,5-disubstituted 1,3,4-oxadiazoles may display potential to provide pharmacologically important heterocyclic compounds. | |
| dc.description.sponsorship | Istanbul University-Cerrahpasa, Scientific Research Projects | en_US |
| dc.identifier.citation | Başpınar Küçük, H., Alhonaish, A., Yıldız, T. ve Güzel, M. (2022). An efficient approach to access 2,5-disubstituted 1,3,4-oxadiazoles by oxidation of 2-arenoxybenzaldehyde N-acyl hydrazones with molecular iodine. ChemistrySelect, 7(26). http://doi.org/10.1002/slct.202201391 | |
| dc.identifier.doi | 10.1002/slct.202201391 | |
| dc.identifier.issn | 2365-6549 | |
| dc.identifier.issue | 26 | |
| dc.identifier.scopus | 2-s2.0-85134028475 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.uri | http://doi.org/10.1002/slct.202201391 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/9587 | |
| dc.identifier.volume | 7 | |
| dc.identifier.wos | 000821936200001 | en_US |
| dc.identifier.wosquality | Q3 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.institutionauthor | Güzel, Mustafa | |
| dc.language.iso | en | |
| dc.publisher | Wiley-VCH Verlag | |
| dc.relation.ispartof | ChemistrySelect | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/embargoedAccess | |
| dc.subject | N-Acylhydrazones | |
| dc.subject | Oxidative Cyclization | |
| dc.subject | 1,3,4-Oxadiazoles | |
| dc.subject | Molecular Iodine | |
| dc.title | An efficient approach to access 2,5-disubstituted 1,3,4-oxadiazoles by oxidation of 2-arenoxybenzaldehyde N-acyl hydrazones with molecular iodine | |
| dc.type | Article |
