Prognostic significance of protein kinase B/Akt pathway in patients with non-small cell lung cancer

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dc.contributor.authorMayadağlı, Alpaslan
dc.contributor.authorKarabulut Gül, Şule
dc.contributor.authorBilici, Ahmet
dc.contributor.authorOruç, Ahmet Fatih
dc.contributor.authorKoçak, Mihriban
dc.contributor.authorÖzkan, Alper
dc.contributor.authorAksu, Atınç
dc.contributor.authorÖzdemir Barışık, Nagehan
dc.contributor.authorGümüş, Mahmut
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:30Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:30Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000334153000023
dc.descriptionPubMed ID: 24659658
dc.description.abstractPurpose: Akt, also known as protein kinase B (PKB), is an intracellular signal transduction protein activated by growth hormones. PKB/Akt is frequently activated in a variety of cancer types, but its role in the development and progression of lung cancer has not been completely elucidated yet. The aim of the present study was to determine the prognostic value of PKB/Akt in non-small cell lung cancer (NSCLC). Methods: A total of 32 tumor samples from NSCLL patients were examined before treatment. The staining characteristics of the cases were evaluated in terms of age, stage (T and N), response to therapy, histological type, tumor size, and ECOG performance status (PS). Results: No statistical correlation was found between PKB/Akt expression and gender, ECOG PS and stage (T and N), while significant correlation between cytoplasmic PKB/akt expression and age was detected (p < 0.05). In addition, squamous cell carcinoma histology was significantly associated with both nuclear and cytoplasmic staining (p=0.033), and tumor size (< 5 cm) was correlated with nuclear PKB/Akt expression (p =0.03). Both overall survival (OS) and progression-free survival (PFS) were similar in patients with and without both nuclear and cytoplasmic PKB/Akt expression. Conclusion: Our results showed that although PKB/Akt was not associated with survival in NSCLC patients, it may be a potential therapeutic target for NSCLC; more studies with higher numbers of patients are needed to verify this hypothesis.
dc.identifier.citationMayadağlı, A., Karabulut Gül, Ş., Bilici, A., Oruç, A. F., Koçak, M., Özkan, A. ... Gümüş, M. (2014). Prognostic significance of protein kinase B/Akt pathway in patients with non-small cell lung cancer. Journal of the Balkan Union of Oncology, 19(1), 157-163.
dc.identifier.endpage163
dc.identifier.issn1107-0625
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.startpage157
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2990
dc.identifier.volume19
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherZerbinis Medical Publications
dc.relation.ispartofJournal of the Balkan Union of Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIntracellular Signal Transduction
dc.subjectNon-Small Cell Lung Cancer
dc.subjectPhospho-Akt (p-Akt)
dc.subjectPrognosis
dc.subjectProtein Kinase B
dc.titlePrognostic significance of protein kinase B/Akt pathway in patients with non-small cell lung cancer
dc.typeArticle

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