The use of breast magnetic resonance imaging parameters to identify possible signaling pathways of a serum biomarker, HE4

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dc.contributor.authorDurur Karakaya, Afak
dc.contributor.authorDurur Subaşı, Irmak
dc.contributor.authorKaraman, Adem
dc.contributor.authorAkçay, Mufide Nuran
dc.contributor.authorPalabıyık, Şaziye Sezin
dc.contributor.authorErdemci, Burak
dc.contributor.authorAlper, Fatih
dc.contributor.authorAcemoğlu, Hamit
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:46Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:46Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.descriptionWOS: 000376906600019
dc.descriptionPubMed ID: 27192502
dc.description.abstractObjectives: This study aimed to investigate the relationship between breast magnetic resonance imaging (MRI) parameters; clinical features such as age, tumor diameter, N, T, and TNM stages; and serum human epididymis protein 4 (HE4) levels in patients with breast carcinoma and use this as a means of estimating possible signaling pathways of the biomarker, HE4. Methods: Thirty-seven patients with breast cancer were evaluated by breast MRI and serum HE4 levels before therapy. Correlations between parameters including age, tumor diameter T and N, dynamic curve type, enhancement ratio (ER), slope wash in (S-WI), time to peak (TTP), slope washout (S-WO), and the serum level of HE4 were investigated statistically. Human epididymis protein 4 levels of early and advanced stage of disease were also compared statistically. Results: Breast MRI parameters showed correlation to serum HE4 levels and correlations were statistically significant. Of these MRI parameters, S-WI had higher correlation coefficient than the others. Human epididymis protein 4 levels were not statistically different in early and advanced stage of disease. Conclusions: High correlation with MRI parameters related to neo-angiogenesis may indicate signaling pathway of HE4.
dc.identifier.citationDurur Karakaya, A., Durur Subaşı, I., Karaman, A., Akçay, M. N., Palabıyık, Ş. S., Erdemci, B. ... Acemoğlu, H. (2016). The use of breast magnetic resonance imaging parameters to identify possible signaling pathways of a serum biomarker, HE4. Journal Of Computer Assisted Tomography, 40(3), 436-441. https://dx.doi.org/10.1097/RCT.0000000000000390
dc.identifier.doi10.1097/RCT.0000000000000390
dc.identifier.endpage441
dc.identifier.issn0363-8715
dc.identifier.issn1532-3145
dc.identifier.issue3
dc.identifier.scopusqualityQ2
dc.identifier.startpage436
dc.identifier.urihttps://dx.doi.org/10.1097/RCT.0000000000000390
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3046
dc.identifier.volume40
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal Of Computer Assisted Tomographyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBreast Cancer
dc.subjectHE4
dc.subjectMagnetic Resonance Imaging
dc.titleThe use of breast magnetic resonance imaging parameters to identify possible signaling pathways of a serum biomarker, HE4
dc.typeArticle

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