Alterations of resting-state Gamma frequency characteristics in aging and Alzheimer's disease

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dc.authorid0000-0002-0860-0524
dc.authorid0000-0002-3941-3019
dc.authorid0000-0003-4292-5717
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorErdal, Furkan
dc.contributor.authorBölükbaş, Burcu
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorYener, Görsev
dc.contributor.authorDuygun, Rümeysa
dc.date.accessioned2023-09-14T07:24:04Z
dc.date.available2023-09-14T07:24:04Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Sinirbilim Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractAlzheimer's disease (AD) is an important brain disease associated with aging. It involves various functional and structural changes which alter the EEG characteristics. Although numerous studies have found changes in delta, theta, alpha, and beta power, fewer studies have looked at the changes in the resting state EEG gamma activity characteristics in AD. This study aimed to investigate the alterations in the frequency and power values of AD patients' resting-state EEG gamma oscillations compared with healthy elderly and young subjects. We performed Fast Fourier Transform (FFT) on the resting state EEG data from 179 participants, including 59 early stage AD patients, 60 healthy elderly, and 60 healthy young subjects. We averaged FFT performed epochs to investigate the power values in the gamma frequency range (28-48 Hz). We then sorted the peaks of power values in the gamma frequency range, and the average of the identified highest three values was named as the gamma dominant peak frequency. The gamma dominant peak frequency of AD patients (Meyes-opened = 33.4 Hz, Meyes-closed = 32.7 Hz) was lower than healthy elderly (Meyes-opened = 35.5 Hz, Meyes-closed = 35.0 Hz) and healthy young subjects (Meyes-opened = 37.2 Hz, Meyes-closed = 37.0 Hz). These results could be related to AD progression and therefore critical for the recent findings regarding the 40 Hz gamma entrainment because it seems they entrain the gamma frequency of AD towards that of healthy young.
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumuen_US
dc.identifier.citationGüntekin, B., Erdal, F., Bölükbaş, B., Hanoğlu, L., Yener, G. ve Duygun, R. (2023). Alterations of resting-state Gamma frequency characteristics in aging and Alzheimer's disease. Cognitive Neurodynamics, 17(4), 829-844. https://dx.doi.org/10.1007/s11571-022-09873-4
dc.identifier.doi10.1007/s11571-022-09873-4
dc.identifier.endpage844
dc.identifier.issn1871-4080
dc.identifier.issn1871-4099
dc.identifier.issue4
dc.identifier.pmid37522051
dc.identifier.scopus2-s2.0-85139248057
dc.identifier.scopusqualityQ3
dc.identifier.startpage829
dc.identifier.urihttps://dx.doi.org/10.1007/s11571-022-09873-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11427
dc.identifier.volume17
dc.identifier.wos000862205800001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüntekin, Bahar
dc.institutionauthorErdal, Furkan
dc.institutionauthorBölükbaş, Burcu
dc.institutionauthorHanoğlu, Lütfü
dc.institutionauthorDuygun, Rümeysa
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofCognitive Neurodynamicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAging
dc.subjectAlzheimer’s Disease
dc.subjectElectroencephalography (EEG)
dc.subjectGamma
dc.subjectGamma Dominant Peak Frequency
dc.subjectGamma Entrainment
dc.titleAlterations of resting-state Gamma frequency characteristics in aging and Alzheimer's disease
dc.typeArticle

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