Eltrombopag for treatment of thrombocytopenia after autologous stem cell transplantation in children single center experience

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dc.contributor.authorBayram, Nihan
dc.contributor.authorYaman, Yöntem
dc.contributor.authorÖzdilli, Kürşat
dc.contributor.authorNepesov, Serdar
dc.contributor.authorOdaman Al, Işık
dc.contributor.authorElli, Murat
dc.contributor.authorAnak, Sema
dc.date.accessioned2025-12-22T07:35:59Z
dc.date.available2025-12-22T07:35:59Z
dc.date.issued2025
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractIntroduction: Thrombocytopenia is a common clinical problem in cancer patients undergoing high-dose chemotherapy and autologous hematopoietic stem cell transplantation (HSCT). It can occur as prolonged isolated thrombocytopenia (PIT) or secondary failure of platelet recovery (SFPR) and may cause potentially fatal bleeding. However, data on the treatment of post-transplant thrombocytopenia is still lacking. Methods: We reported our practices involving 15 pediatric patients who received eltrombopag (ELT) treatment for PIT and SFPR after autologous HSCT. Results: The overall response was 78.5% (11/14), with 1 patient excluded due to noncompliance. The 12 surviving patients' median follow up was 699 days (range: 167 to 2250 d). Conclusions: Our study indicates the efficacy and safety of ELT for treating PIT and SFPR after autologous HSCT in pediatric patients. However, more studies are needed to confirm these findings in children.
dc.identifier.citationBayram, N., Yaman, Y., Özdilli, K., Nepesov, S., Odaman Al, I., Elli, M. ... Anak, S. (2025). Eltrombopag for treatment of thrombocytopenia after autologous stem cell transplantation in children single center experience. Journal of Pediatric Hematology/Oncology, 47(1), e10-e14. http://dx.doi.org/10.1097/MPH.0000000000002971
dc.identifier.doi10.1097/MPH.0000000000002971
dc.identifier.endpagee14
dc.identifier.issn1077-4114
dc.identifier.issn1536-3678
dc.identifier.issue1
dc.identifier.pmid39737632
dc.identifier.scopus2-s2.0-85214189210
dc.identifier.scopusqualityQ3
dc.identifier.startpagee10
dc.identifier.urihttp://dx.doi.org/10.1097/MPH.0000000000002971
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13344
dc.identifier.volume47
dc.identifier.wosWOS:001386353700003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYaman, Yöntem
dc.institutionauthorÖzdilli, Kürşat
dc.institutionauthorOdaman Al, Işık
dc.institutionauthorAnak, Sema
dc.institutionauthorid0000-0002-9710-8653
dc.institutionauthorid0000-0002-7129-5024
dc.institutionauthorid0000-0001-8489-7449
dc.language.isoen
dc.relation.ispartofJournal of Pediatric Hematology/Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAutologous Stem Cell Transplantation
dc.subjectEltrombopag
dc.subjectThrombocytopenia
dc.titleEltrombopag for treatment of thrombocytopenia after autologous stem cell transplantation in children single center experience
dc.typeArticle

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