ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury

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dc.authorid0000-0002-9476-8488
dc.authorid0000-0001-6494-8923
dc.contributor.authorRohlfing, Anne-Katrin
dc.contributor.authorKolb, Kyra
dc.contributor.authorSigle, Manuel
dc.contributor.authorZiegler, Melanie
dc.contributor.authorBild, Alexander
dc.contributor.authorMünzer, Patrick
dc.contributor.authorSudmann, Jessica
dc.contributor.authorDicenta, Valerie
dc.contributor.authorHarm, Tobias
dc.contributor.authorManke, Mailin-Christin
dc.contributor.authorGeue, Sascha
dc.contributor.authorKremser, Marcel
dc.contributor.authorChatterjee, Madhumita
dc.contributor.authorLiang, Chunguang
dc.contributor.authorEysmondt, Hendrik von
dc.contributor.authorDandekar, Thomas
dc.contributor.authorHeinzmann, David
dc.contributor.authorGünter, Manina
dc.contributor.authorUngern-Sternberg, Saskia von
dc.contributor.authorBüttcher, Manuela
dc.contributor.authorCastor, Tatsiana
dc.contributor.authorMencl, Stine
dc.contributor.authorLanghauser, Friederike
dc.contributor.authorSies, Katharina
dc.contributor.authorAshour, Diyaa
dc.contributor.authorBeker, Mustafa Çağlar
dc.contributor.authorLämmerhofer, Michael
dc.contributor.authorAutenrieth, Stella E.
dc.contributor.authorSchäffer, Tilman E.
dc.contributor.authorLaufer, Stefan
dc.contributor.authorSzklanna, Paulina
dc.contributor.authorMaguire, Patricia
dc.contributor.authorHeikenwalder, Matthias
dc.contributor.authorMüller, Karin Anne Lydia
dc.contributor.authorHermann, Dirk M.
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorStumm, Ralf
dc.contributor.authorRamos, Gustavo
dc.contributor.authorKleinschnitz, Christoph
dc.contributor.authorBorst, Oliver
dc.contributor.authorLanger, Harald F.
dc.contributor.authorRath, Dominik
dc.contributor.authorGawaz, Meinrad
dc.date.accessioned2022-04-22T06:40:53Z
dc.date.available2022-04-22T06:40:53Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractPlatelet activation plays a critical role in thrombosis. Inhibition of platelet activation is a cornerstone in treatment of acute organ ischemia. Platelet ACKR3 surface expression is independently associated with all-cause mortality in CAD patients. In a novel genetic mouse strain, we show that megakaryocyte/platelet-specific deletion of ACKR3 results in enhanced platelet activation and thrombosis in vitro and in vivo. Further, we performed ischemia/reperfusion experiments (transient LAD-ligation and tMCAO) in mice to assess the impact of genetic ACKR3 deficiency in platelets on tissue injury in ischemic myocardium and brain. Loss of platelet ACKR3 enhances tissue injury in ischemic myocardium and brain and aggravates tissue inflammation. Activation of platelet-ACKR3 via specific ACKR3 agonists inhibits platelet activation and thrombus formation and attenuates tissue injury in ischemic myocardium and brain. Here we demonstrate that ACKR3 is a critical regulator of platelet activation, thrombus formation and organ injury following ischemia/reperfusion.
dc.identifier.citationRohlfing, A.-K., Kolb, K., Sigle, M., Ziegler, M., Bild, A., Münzer, P. ... Gawaz, M. (2022). ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-29341-1
dc.identifier.doi10.1038/s41467-022-29341-1
dc.identifier.issue1
dc.identifier.pmid35383158
dc.identifier.scopus2-s2.0-85127721441
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1038/s41467-022-29341-1
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9351
dc.identifier.volume13
dc.identifier.wos000782237700034en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBeker, Mustafa Çağlar
dc.institutionauthorKılıç, Ertuğrul
dc.language.isoen
dc.publisherNature Research
dc.relation.ispartofNature Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectACKR3
dc.subjectIschemiareperfusion Tissue Injury
dc.subjectPlatelet Activation
dc.titleACKR3 regulates platelet activation and ischemia-reperfusion tissue injury
dc.typeArticle

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