Comparison of platelet-rich plasma efficacy with and without photoactivation in melasma: A randomized double-blind study
| dc.contributor.author | Topaloğlu Demir, Filiz | |
| dc.contributor.author | Altun, Ece | |
| dc.date.accessioned | 2025-03-07T06:54:43Z | |
| dc.date.available | 2025-03-07T06:54:43Z | |
| dc.date.issued | 2024 | |
| dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıklar Ana Bilim Dalı | |
| dc.description.abstract | Background: Photoactivation has been suggested to enhance the efficacy of platelet-rich plasma (PRP) in conditions other than dermatological diseases. Aims: To evaluate the efficacy of photoactivated PRP (P-PRP) treatment for melasma by comparing it with non-photoactivated, classical PRP (C-PRP). Methods: The study consisted of 38 female patients diagnosed with melasma between April 2022 and May 2023. The patients were randomized into the P-PRP and C-PRP groups. Three sessions of P-PRP or C-PRP were applied to the patients at 2-week intervals. The Melasma Area and Severity Index (MASI) and Melasma Quality of Life Index (MELASQoL) scores were compared before and 2 weeks after treatment. Results: The median age was 38 years, and the median disease duration was 60 months. Clinically, 94.7% of the cases were centrofacial and 5.3% were malar. According to Wood's lamp examination, 55.3% of the cases were epidermal, 13.2% were dermal, and 31.6% were mixed-type. The median pre- and post-treatment scores were 14.5 and 9, respectively, for MASI and 36.5 and 17, respectively, for MELASQoL. The post-treatment MASI and MELASQoL scores of both groups significantly decreased (p < 0.001 for both). However, the intergroup difference was not significant. When all patients were evaluated together a moderate, positive, and significant relationship was detected between PRP and the pre- and post-treatment MASI and MELASQoL scores (r = 0.494 and p = 0.002). No side effects associated with PRP were observed. Conclusion: PRP is an effective and safe treatment method for melasma. Further studies are needed to evaluate the contribution of photoactivation to PRP treatment in melasma. | |
| dc.identifier.citation | Topaloğlu Demir, F. ve Altun, E. (2024). Comparison of platelet-rich plasma efficacy with and without photoactivation in melasma: A randomized double-blind study. Journal of Cosmetic Dermatology, 23(12), 3911-3917. http://dx.doi.org/10.1111/jocd.16540 | |
| dc.identifier.doi | 10.1111/jocd.16540 | |
| dc.identifier.endpage | 3917 | |
| dc.identifier.issn | 1473-2130 | |
| dc.identifier.issn | 1473-2165 | |
| dc.identifier.issue | 12 | |
| dc.identifier.pmid | 39175423 | |
| dc.identifier.scopus | 2-s2.0-85201958606 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.startpage | 3911 | |
| dc.identifier.uri | http://dx.doi.org/10.1111/jocd.16540 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/12891 | |
| dc.identifier.volume | 23 | |
| dc.identifier.wos | WOS:001296531100001 | |
| dc.identifier.wosquality | Q2 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.institutionauthor | Topaloğlu Demir, Filiz | |
| dc.institutionauthor | Altun, Ece | |
| dc.institutionauthorid | 0000-0002-2049-1316 | |
| dc.institutionauthorid | 0000-0002-8118-3405 | |
| dc.language.iso | en | |
| dc.relation.ispartof | Journal of Cosmetic Dermatology | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | Attribution 4.0 International | * |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject | Melasma | |
| dc.subject | Photoactivation | |
| dc.subject | Platelet-Rich Plasma | |
| dc.title | Comparison of platelet-rich plasma efficacy with and without photoactivation in melasma: A randomized double-blind study | |
| dc.type | Article |
