Tumor necrosis factor-alpha (TNF-alpha)-238 G/A polymorphism is associated with the treatment resistance and attempted suicide in schizophrenia

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dc.authorid0000-0002-7129-5024
dc.contributor.authorAytaç, Hasan Mervan
dc.contributor.authorÖzdilli, Kürşat
dc.contributor.authorTuncel, Fatıma Ceren
dc.contributor.authorPehlivan, Mustafa
dc.contributor.authorPehlivan, Sacide
dc.date.accessioned2021-04-01T08:22:43Z
dc.date.available2021-04-01T08:22:43Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractAbnormality of the immune system may play an important role in the pathogenesis of schizophrenia (SCZ). We aim to investigate the relationship between clinical features of SCZ and tumor necrosis factor-alpha (TNF-?) -238 G/A, -308 G/A polymorphisms in SCZ patients by comparing genotype distributions of TNF-? gene polymorphisms between patients and healthy controls. A sample of 113 patients with SCZ and 104 healthy volunteers was included in the study. SCID-I was used to confirming the diagnosis according to DSM-IV-TR criteria. We evaluated the patients with some scales and data forms in terms of clinical features, symptom severity, level of insight, suicidal behavior, and treatment response. PCR-RFLP was used to determine TNF-? gene polymorphisms from DNA material. The distributions of TNF-? - 238 G/A and TNF-? - 308 G/A polymorphisms of the patients diagnosed with SCZ were not significantly different from the control group. There was a significant difference in the TNF-? - 238 G/A genotype distributions between treatment-resistant and treatment-responsive SCZ patients. Again, the distributions of TNF-? - 238 G/A genotype of attempted suicide patients in SCZ were significantly different from the non-attempted suicide of SCZ patients. Whereas TNF-? - 238 G/A and -308 G/A polymorphisms were not associated with SCZ, TNF-? - 238 G/A polymorphism may be related to treatment resistance and attempted suicide in SCZ patients in the Turkish population.
dc.identifier.citationAytaç, H. M., Özdilli, K., Tuncel, F. C., Pehlivan, M. ve Pehlivan, S. (2022). Tumor necrosis factor-alpha (TNF-alpha)-238 G/A polymorphism is associated with the treatment resistance and attempted suicide in schizophrenia. Immunological Investigations, 51(2), 368-380. https://doi.org/10.1080/08820139.2020.1832115
dc.identifier.doi10.1080/08820139.2020.1832115
dc.identifier.endpage380
dc.identifier.issn0882-0139
dc.identifier.issn1532-4311
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage368
dc.identifier.urihttps://doi.org/10.1080/08820139.2020.1832115
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6670
dc.identifier.volume51
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofImmunological Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSchizophrenia
dc.subjectAttempted Suicide
dc.subjectSingle Nucleotide Polymorphism
dc.subjectTnf-a
dc.subjectTreatment Resistance
dc.titleTumor necrosis factor-alpha (TNF-alpha)-238 G/A polymorphism is associated with the treatment resistance and attempted suicide in schizophrenia
dc.title.alternativeTumor necrosis factor-alpha (TNF-?) ?238 G/A polymorphism ıs associated with the treatment resistance and attempted suicide in schizophrenia
dc.typeArticle

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