Time dependent impact of perinatal hypoxia on growth hormone, insulin-like growth factor 1 and insulin-like growth factor binding protein-3

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dc.authorid0000-0003-3616-1204
dc.authorid0000-0002-6242-3709
dc.authorid0000-0002-9476-8488
dc.authorid0000-0002-9704-6173
dc.authorid0000-0001-6494-8923
dc.contributor.authorKartal, Ömer
dc.contributor.authorAydınöz, Seçil
dc.contributor.authorKartal, Ayşe Tuğba
dc.contributor.authorKeleştemur, Taha
dc.contributor.authorÇağlayan, Ahmet Burak
dc.contributor.authorBeker, Mustafa Çağlar
dc.contributor.authorKarademir, Ferhan
dc.contributor.authorSüleymanoğlu, Selami
dc.contributor.authorKul, Mustafa
dc.contributor.authorYuluğ, Burak
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:46Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:46Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.descriptionWOS: 000379187900010
dc.descriptionPubMed ID: 26943480
dc.description.abstractHypoxic-ischemia (HI) is a widely used animal model to mimic the preterm or perinatal sublethal hypoxia, including hypoxic-ischemic encephalopathy. It causes diffuse neurodegeneration in the brain and results in mental retardation, hyperactivity, cerebral palsy, epilepsy and neuroendocrine disturbances. Herein, we examined acute and subacute correlations between neuronal degeneration and serum growth factor changes, including growth hormone (GH), insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) after hypoxic-ischemia (HI) in neonatal rats. In the acute phase of hypoxia, brain volume was increased significantly as compared with control animals, which was associated with reduced GH and IGF-1 secretions. Reduced neuronal survival and increased DNA fragmentation were also noticed in these animals. However, in the subacute phase of hypoxia, neuronal survival and brain volume were significantly decreased, accompanied by increased apoptotic cell death in the hippocampus and cortex. Serum GH, IGF-1, and IGFBP-3 levels were significantly reduced in the subacute phase of HI. Significant retardation in the brain and body development were noted in the subacute phase of hypoxia. Here, we provide evidence that serum levels of growth-hormone and factors were decreased in the acute and subacute phase of hypoxia, which was associated with increased DNA fragmentation and decreased neuronal survival.
dc.description.sponsorshipEMBO (European Molecular Biology Organization); Turkish Academy of Sciences (TUBA)en_US
dc.description.sponsorshipThis work was supported by EMBO (European Molecular Biology Organization) installation Grant and The Turkish Academy of Sciences (TUBA).en_US
dc.identifier.citationKartal, Ö., Aydınöz, S., Kartal, A. T., Keleştemur, T., Çağlayan, A. B., Beker, M. Ç. ... Kılıç, E. (2016). Time dependent impact of perinatal hypoxia on growth hormone, insulin-like growth factor 1 and insulin-like growth factor binding protein-3. Metabolic Brain Disease, 31(4), 827-835. https://dx.doi.org/10.1007/s11011-016-9816-z
dc.identifier.doi10.1007/s11011-016-9816-z
dc.identifier.endpage835
dc.identifier.issn0885-7490
dc.identifier.issn1573-7365
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage827
dc.identifier.urihttps://dx.doi.org/10.1007/s11011-016-9816-z
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3439
dc.identifier.volume31
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofMetabolic Brain Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectPerinatal Hypoxia
dc.subjectBrain Injury
dc.subjectApoptosis
dc.subjectSerum GH
dc.subjectIGF-1
dc.subjectIGFBP-3 Levels
dc.titleTime dependent impact of perinatal hypoxia on growth hormone, insulin-like growth factor 1 and insulin-like growth factor binding protein-3
dc.typeArticle

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