Expression of Pea3 protein subfamily members in hippocampus and potential regulation following neuronal stimulation

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dc.authorid0000-0001-9037-5217
dc.authorid0000-0003-0352-1947
dc.contributor.authorKandemir, Başak
dc.contributor.authorDavis, Sabrina
dc.contributor.authorYiğit, Esra Nur
dc.contributor.authorÖztürk, Gürkan
dc.contributor.authorYılmaz, Bayram
dc.contributor.authorLaroche, Serge
dc.contributor.authorAksan Kurnaz, Işıl
dc.date.accessioned2020-11-13T06:30:22Z
dc.date.available2020-11-13T06:30:22Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.description.abstractPea3 proteins belong to a subfamily of the E-twentysix (ETS) domain superfamily of transcription factors, which play various roles during development. Polyoma Enhancer-Activator 3 (Pea3) proteins Pea3, ERM and Er81 are particularly involved in tissues with branching morphogenesis, including kidney, lung, mammary gland and nervous system development. A recent transcriptomic study on novel targets of Pea3 transcription factor revealed various axon guidance and nervous system development related targets, supporting a role of Pea3 proteins in motor neuron connectivity, as well as novel targets in signaling pathways involved in synaptic plasticity. This study focuses on the expression of Pea3 family members in hippocampal neurons, and regulation of putative Pea3 targets in Pea3-overexpressing cell lines and following induction of long-term potentiation or seizure in vivo. We show that Pea3 proteins are expressed in hippocampus in both neuronal and non-neuronal cells, and that Pea3 represses Elk-1 but activates Prkca and Nrcam expression in hippocampal cell lines. We also show that mRNA and protein levels of Pea3 family members are differentially regulated in the dentate gyrus and CA1 region upon MECS stimulation, but not upon LTP induction.
dc.description.sponsorshipUniversity Paris-Saclay, CNRS (Centre National de la Recherche Scientifique), Franceen_US
dc.identifier.citationKandemir, B., Davis, S., Yiğit, E. N., Öztürk, G., Yılmaz, B., Laroche, S. ... Aksan Kurnaz, I. (2020). Expression of Pea3 protein subfamily members in hippocampus and potential regulation following neuronal stimulation. Neuroscience Letters, 738. https://dx.doi.org/10.1016/j.neulet.2020.135348
dc.identifier.doi10.1016/j.neulet.2020.135348
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1016/j.neulet.2020.135348
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6024
dc.identifier.volume738
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ecinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/107S064 214Z278
dc.relation.ecinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/2214-A
dc.relation.ispartofNeuroscience Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectPea3
dc.subjectHippocampus
dc.subjectLTP
dc.titleExpression of Pea3 protein subfamily members in hippocampus and potential regulation following neuronal stimulation
dc.typeArticle

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