Investigation of the effects of curcumin and gallic acid in the liver and kidneys of rat ovarian transplant recipients

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dc.contributor.authorKeleş, Papatya
dc.contributor.authorSapmaz, Tansel
dc.contributor.authorBaşol Baki, Kübra
dc.contributor.authorTopkaraoğlu, Sude
dc.contributor.authorErdem, Esra
dc.contributor.authorPençe, Mahmud Esad
dc.contributor.authorKarip, Burak
dc.date.accessioned2025-10-16T08:18:29Z
dc.date.available2025-10-16T08:18:29Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjectives: Recent studies have shown that oxidative stress, inflammation, and apoptosis play substantial roles in the pathogenesis of tissue damage and distant organ damage during ovarian transplantation. Because of their potential antioxidant and anti-inflammatory properties, investigating natural compounds like curcumin and gallic acid is crucial. This study investigated the effects of curcumin, gallic acid, and their combination on liver and kidney tissues in a rat model of ovarian transplantation. Materials and Methods: For this study, we used 42 adult female Sprague-Dawley rats aged 11 to 12 weeks, which we randomly divided into 6 groups. After the transplant procedures, we performed histopathological analysis, biochemical examinations, and statistical analysis. Results: Significant damage was shown in the liver and kidney tissues of the ovarian transplant only and transplant plus corn oil groups compared with the control group, as evidenced by histopathological evaluation, increased BAX/BCL-2 intensity indicating apoptotic activity, and elevated interleukin 6 levels. However, treatment with curcumin, gallic acid, or their combination attenuated these adverse effects, suggesting potential protective effects against transplant-induced injury. Conclusions: Our findings highlight the therapeutic potential of these compounds in mitigating tissue damage and inflammation associated with ovarian transplant.
dc.identifier.citationKeleş, P., Sapmaz, T., Başol Baki, K., Topkaraoğlu, S., Erdem, E., Pençe, M. E. ... Karip, B. (2024). Investigation of the effects of curcumin and gallic acid in the liver and kidneys of rat ovarian transplant recipients. Experimental and Clinical Transplantation, 22(9), 706-716. http://dx.doi.org/10.6002/ect.2023.0327
dc.identifier.doi10.6002/ect.2023.0327
dc.identifier.endpage716
dc.identifier.issn1304-0855
dc.identifier.issn2146-8427
dc.identifier.issue9
dc.identifier.pmid39431839
dc.identifier.scopus2-s2.0-85206872143
dc.identifier.scopusqualityQ3
dc.identifier.startpage706
dc.identifier.urihttp://dx.doi.org/10.6002/ect.2023.0327
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13112
dc.identifier.volume22
dc.identifier.wosWOS:001347818700008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorPençe, Mahmud Esad
dc.language.isoen
dc.relation.ispartofExperimental and Clinical Transplantation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnimal Model
dc.subjectDistant Organ Damage
dc.subjectIschemia-Reperfusion Injury
dc.subjectTransplant-Induced Injury
dc.titleInvestigation of the effects of curcumin and gallic acid in the liver and kidneys of rat ovarian transplant recipients
dc.typeArticle

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