Hepatitis B virus e antigen (HBeAg) may have a negative effect on dendritic cell generation

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dc.authorid0000-0002-8814-7351
dc.contributor.authorHatipoğlu, İbrahim
dc.contributor.authorErcan, Duygu
dc.contributor.authorAçılan, Ceyda
dc.contributor.authorBaşalp, Aynur
dc.contributor.authorDurali, Deniz
dc.contributor.authorBaykal, Ahmet Tarık
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:22Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:22Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.descriptionWOS: 000345541900006
dc.descriptionPubMed ID: 25150150
dc.description.abstractHepatitis B virus (HBV) continues to be a serious worldwide health problem despite the use of protective HBV vaccines and therapeutic regimens against chronic HBV infection. Chronic HBV patients cannot induce sufficient immune responses against the virus. HBV and its antigens are believed to suppress immune responses during chronic infection. Hence, studying the role of HBV in immune suppression is very important for the development of alternative therapeutic strategies for HBV infections. In the present study, we investigated the effect of Hepatitis B virus e antigen (HBeAg) on the generation of bone marrow derived dendritic cells (BMDCs) and the stimulation of plasmacytoid DCs (pDCs). In the presence of HBeAg, the ratio of BMDCs was decreased, but the ratio of CD11b(+)Ly6G(+) immature myeloid cells was increased. The expression of 47 proteins was also changed during HBeAg treatment; however, CpG-induced MHC-II expression on pDCs was not affected. Our results indicate that HBeAg may have a negative effect on the generation of DCs from bone morrow precursors. (C) 2014 Elsevier GmbH. All rights reserved.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [108S300, 110S497, 105G0656]en_US
dc.description.sponsorshipThis study was supported by grants nos. 108S300, 110S497 and 105G0656 from The Scientific and Technological Research Council of Turkey (TUBITAK). We thank Dr. Betul Guloglu for critically reviewing the manuscript and Duygu OZCELIK for her excellent technical assistance.en_US
dc.identifier.citationHatipoğlu, İ., Ercan, D., Açılan, C., Başalp, A., Durali, D. ve Baykal, A. T. (2014). Hepatitis B virus e antigen (HBeAg) may have a negative effect on dendritic cell generation. Immunobiology, 219(12), 944-949. https://dx.doi.org/10.1016/j.imbio.2014.07.020
dc.identifier.doi10.1016/j.imbio.2014.07.020
dc.identifier.endpage949
dc.identifier.issn0171-2985
dc.identifier.issue12
dc.identifier.scopusqualityQ1
dc.identifier.startpage944
dc.identifier.urihttps://dx.doi.org/10.1016/j.imbio.2014.07.020
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2681
dc.identifier.volume219
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofImmunobiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/108S300
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/110S497
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/105G0656
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDendritic Cell
dc.subjectHBeAg
dc.subjectHepatitis B Virus
dc.subjectLC-MS/MS
dc.subjectProteomics
dc.titleHepatitis B virus e antigen (HBeAg) may have a negative effect on dendritic cell generation
dc.typeArticle

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