Dosimetric comparison of helical tomotherapy, intensity-modulated radiation therapy, volumetric-modulated arc therapy, and 3-dimensional conformal therapy for the treatment of T1N0 glottic cancer

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dc.contributor.authorEkici, Kemal
dc.contributor.authorKaya Pepele, Eda
dc.contributor.authorYaprak, Bahaddin
dc.contributor.authorTemelli, Öztun
dc.contributor.authorEraslan, Aysun Fatma
dc.contributor.authorKüçük, Nadir
dc.contributor.authorYıldırım Altınok, Ayşe
dc.contributor.authorAltınok Süt, Pelin
dc.contributor.authorAlpak, Özlem D.
dc.contributor.authorÇolak, Cemil
dc.contributor.authorMayadağlı, Alpaslan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:42Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:42Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.descriptionWOS: 000389011500012
dc.descriptionPubMed ID: 27765542
dc.description.abstractVarious radiotherapy planning methods for T1N0 laryngeal cancer have been proposed to decrease normal tissue toxicity. We compare helical tomotherapy (HT), linac-based intensity-modulated radiation therapy (IMRT), volumetric-modulated arc therapy (VMAT), and 3-D conformal radiotherapy (3D-CRT) techniques for T1N0 laryngeal cancer. Overall, 10 patients with T1N0 laryngeal cancer were selected and evaluated. Furthermore, 10 radiotherapy treatment plans have been created for all 10 patients, including HT, IMRT, VMAT, and 3D-CRT. IMRT, VMAT, and HT plans vs 3D-CRT plans consistently provided superior planning target volume (PTV) coverage. Similar target coverage was observed between the 3 IMRT modalities. Compared with 3D-CRT, IMRT, HT, and VMAT significantly reduced the mean dose to the carotid arteries. VMAT resulted in the lowest mean dose to the submandibular and thyroid glands. Compared with 3D-CRT, IMRT, HT, and VMAT significantly increased the maximum dose to the spinal cord It was observed that the 3 IMRT modalities studied showed superior target coverage with less variation between each plan in comparison with 3D-CRT. The 3D-CRT plans performed better at the Dmax of the spinal cord. Clinical investigation is warranted to determine if these treatment approaches would translate into a reduction in radiation therapy-induced toxicities.
dc.identifier.citationEkici, K., Kaya Pepele, E., Yaprak, B., Temelli, Ö., Eraslan, A. F., Küçük, N. ... Mayadağlı, A. (2016). Dosimetric comparison of helical tomotherapy, intensity-modulated radiation therapy, volumetric-modulated arc therapy, and 3-dimensional conformal therapy for the treatment of T1N0 glottic cancer. Medical Dosimetry, 41(4), 329-333. https://dx.doi.org/10.1016/j.meddos.2016.08.002
dc.identifier.doi10.1016/j.meddos.2016.08.002
dc.identifier.endpage333
dc.identifier.issn0958-3947
dc.identifier.issn1873-4022
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage329
dc.identifier.urihttps://dx.doi.org/10.1016/j.meddos.2016.08.002
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3409
dc.identifier.volume41
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofMedical Dosimetryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLarynx Cancer
dc.subjectHelical Tomotherapy
dc.subjectVolumetric Arc Therapy
dc.subjectIntensity-Modulated Radiotherapy
dc.titleDosimetric comparison of helical tomotherapy, intensity-modulated radiation therapy, volumetric-modulated arc therapy, and 3-dimensional conformal therapy for the treatment of T1N0 glottic cancer
dc.typeArticle

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