What is the optimal treatment in clinical stage T3N0M0 rectal cancer?

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dc.contributor.authorTural, Deniz
dc.contributor.authorYıldız, Özcan
dc.contributor.authorElçin, Olgun
dc.contributor.authorErdamar, Sibel
dc.contributor.authorGüney, Sabri
dc.contributor.authorDemireli, Fuat
dc.contributor.authorBüyükünal, Evin
dc.contributor.authorSerdengeçti, Süheyla
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:30Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:30Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000334153000014
dc.descriptionPubMed ID: 24659649
dc.description.abstractPurpose: Some previous studies suggested that certain rectal cancer patients with stage T3N0 and favorable features may be adequately treated with surgery and adjuvant chemotherapy. However, the optimal management of clinical (c) T3N0 rectal adenocarcinoma based on preoperative imaging is unclear. In this study, we aimed to determine the frequency of lymph node metastases in patients clinically staged as T3N0 rectal adenocarcinoma following preoperative chemoradiotherapy (CTR). Methods: The medical records of 105 patients with clinico-imaging stage T3N0M0 rectal cancer who received preoperative CRT between 2004-2011 were retrospectively analyzed. Chemotherapy used concurrently with preoperative radiotherapy (RT) was protracted 5-fluorouracil (5FU) infusion. Results: Twenty-seven percent of the patients clinically staged as T3N0 before preoperative CRT had pathological (p) lymph node involvement on surgical material. The rate of pathological lymph node involvement was 0% in pT1, 20% in pT2, 35% in pT3 and 34% in pT4 patients. A significant association was demonstrated between pT stages and pN status (p=-0.03). Conclusion: Our study demonstrated that the accuracy of preoperative imaging for staging rectal cancer is limited because at least 27% of the patients may have undetected lymph node involvement after preoperative CRT in surgical material.
dc.identifier.citationTural, D., Yıldız, Ö., Elçin, O., Erdamar, S., Güney, S. Demireli, F. ... Serdengeçti, S. (2014). What is the optimal treatment in clinical stage T3N0M0 rectal cancer? Journal of the Balkan Union of Oncology, 19(1), 97-102.
dc.identifier.endpage102
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.startpage97
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2991
dc.identifier.volume19
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherZerbinis Medical Publications
dc.relation.ispartofJournal of the Balkan Union of Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectClinical T3
dc.subjectN0 Rectal Adenocarcinoma
dc.subjectPreoperative Imaging
dc.subjectUnderstaged
dc.titleWhat is the optimal treatment in clinical stage T3N0M0 rectal cancer?
dc.typeArticle

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