Exenatide promotes regeneration of injured rat sciatic nerve

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dc.authorid0000-0003-3976-9530
dc.contributor.authorKuyucu, Ersin
dc.contributor.authorGümüş, Bilal
dc.contributor.authorErbaş, Oytun
dc.contributor.authorOltulu, Fatih
dc.contributor.authorBora, Arslan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:54Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:54Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalı
dc.descriptionWOS: 000400920000028
dc.descriptionPubMed ID: 28553346
dc.description.abstractDamage to peripheral nerves results in partial or complete dysfunction. After peripheral nerve injuries, a full functional recovery usually cannot be achieved despite the standard surgical repairs. Neurotrophic factors and growth factors stimulate axonal growth and support the viability of nerve cells. The objective of this study is to investigate the neurotrophic effect of exenatide (glucagon like peptide-1 analog) in a rat sciatic nerve neurotmesis model. We injected 10 mg/d exenatide for 12 weeks in the experimental group (n = 12) and 0.1 mL/d saline for 12 weeks in the control group (n = 12). We evaluated nerve regeneration by conducting electrophysiological and motor functional tests. Histological changes were evaluated at weeks 1, 3, 6, and 9. Nerve regeneration was monitored using stereomicroscopy. The electrophysiological and motor functions in rats treated with exenatide were improved at 12 weeks after surgery. Histological examination revealed a significant increase in the number of axons in injured sciatic nerve following exenatide treatment confirmed by stereomicroscopy. In an experimentally induced neurotmesis model in rats, exenatide had a positive effect on nerve regeneration evidenced by electromyography, functional motor tests, histological and stereomicroscopic findings.
dc.identifier.citationKuyucu, E., Gümüş, B., Erbaş, O., Oltulu, F. ve Bora, A. (2017). Exenatide promotes regeneration of injured rat sciatic nerve. Neural Regeneration Research, 12(4), 637-643. https://dx.doi.org/10.4103/1673-5374.205105
dc.identifier.doi10.4103/1673-5374.205105
dc.identifier.endpage643
dc.identifier.issn1673-5374
dc.identifier.issn1876-7958
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage637
dc.identifier.urihttps://dx.doi.org/10.4103/1673-5374.205105
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3488
dc.identifier.volume12
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofNeural Regeneration Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0/*
dc.subjectNerve Regeneration
dc.subjectSciatic Nerve
dc.subjectGlucagon Like Peptid 1
dc.subjectElectromyography
dc.subjectStereomicroscopy
dc.subjectHistology
dc.subjectNeural Regeneration
dc.titleExenatide promotes regeneration of injured rat sciatic nerve
dc.typeArticle

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