Is high platelet distribution width in the first hours of life can predict hemodynamically significant patent ductus arteriosus in preterm newborns?

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dc.authorid0000-0003-1735-4318
dc.contributor.authorDemirel, Gamze
dc.contributor.authorYılmaz, Aslan
dc.contributor.authorVatansever, Binay
dc.contributor.authorTaştekin, Ayhan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:23Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:23Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractAim: To determine whether there is any association between platelet indices within the first hours of life and hemodynamically significant patent ductus arteriosus (hsPDA) in preterm newborns. Patient and methods: A total of 100 preterm infants, gestational age <32 weeks and birth weight <1500 g were analyzed in the study. Complete blood counts obtained within the first 6 hours of life were evaluated for platelet parameters and compared for patent ductus arteriosus (PDA) status. Results: We included 50 infants with hsPDA and 50 controls. Mean gestational week of patients were 28.8 ± 2.4 weeks and mean birth weight of the patients were 1237.5 ± 406 g. Platelet distribution width (PDW) is higher in PDA group compared with the control group (p =.023). The cutoff value of PDW is 11.45 fL for hsPDA with 65% sensitivity and 66% specificity. The other blood parameters including platelet count, platelet mass, and mean platelet volume (MPV) were no statistically different between the two groups. Also, there was no association with the platelet count and the response to the medical therapy. Conclusions: There is no association between hsPDA and the platelet count, platelet mass or MPV in the first day of life. We determined that hsPDA patency was significantly associated with a higher first day PDW level, which is a more specific indicator of platelet activation than other platelet parameters.
dc.identifier.citationDemirel, G., Yılmaz, A., Vatansever, B. ve Taştekin, A. (2020). Is high platelet distribution width in the first hours of life can predict hemodynamically significant patent ductus arteriosus in preterm newborns? Journal of Maternal-Fetal and Neonatal Medicine. 33(12), 2049-2053. https://dx.doi.org/10.1080/14767058.2018.1536743
dc.identifier.doi10.1080/14767058.2018.1536743
dc.identifier.endpage2053
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue12
dc.identifier.scopusqualityQ2
dc.identifier.startpage2049
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1147
dc.identifier.urihttps://dx.doi.org/10.1080/14767058.2018.1536743
dc.identifier.volume33
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Ltd
dc.relation.ispartofJournal of Maternal-Fetal and Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPatent Ductus Arteriosus
dc.subjectPlatelet
dc.subjectPlatelet Distribution Width
dc.subjectPreterm
dc.titleIs high platelet distribution width in the first hours of life can predict hemodynamically significant patent ductus arteriosus in preterm newborns?
dc.typeArticle

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