Hydrogen-rich saline reduces tissue injury and improves skin flap survival on a rat hindlimb degloving injury model
| dc.authorid | 0000-0003-0908-1719 | |
| dc.contributor.author | Ergan Şahin, Ayça | |
| dc.contributor.author | Karasoy Yeşilada, Ayşin | |
| dc.contributor.author | Yalçın, Özben | |
| dc.contributor.author | Güler, Eray Metin | |
| dc.contributor.author | Erbek, Harun | |
| dc.contributor.author | Karabıyık, Damla | |
| dc.date.accessioned | 2021-10-13T12:18:15Z | |
| dc.date.available | 2021-10-13T12:18:15Z | |
| dc.date.issued | 2021 | |
| dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı | |
| dc.description.abstract | Background: Degloving injuries represent a challenge in plastic surgery. The aim of this study is to acknowledge the protective effects of hydrogen-rich saline (HRS) solution on a rat hindlimb degloved skin flap. Methods: Twenty-one Sprague–Dawley rats were divided into three groups (control, saline and HRS). Degloving injury model was established, and flaps were sutured back following 5 min of ischemia. The control group did not receive any treatment. The saline group received intraperitoneal physiological saline (10 ml/kg) and the HRS group received intraperitoneal HRS solution (10 ml/kg) postoperatively and daily for 5 days after the operation. Skin samples were obtained for histological, immunohistochemical and biochemical evaluations. Results: Inflammation was lower in the HRS compared with saline (p = 0.02) and control (p = 0.004) groups. Edema was lower in the HRS compared with saline (p = 0.02) and control (p = 0.001) groups. Malondialdehyde (MDA) level was lower in the HRS than the control group (p = 0.01). Total antioxidant level was higher in the HRS compared with saline (p = 0.009) and control (p = 0.03) groups. Total oxidant level was lower in the HRS than the control group (p = 0.02). Oxidative stress index was lower in the HRS compared with saline (p = 0.001) and control (p = 0.0001) groups`. Vascular proliferation was higher in the HRS compared with the control group (p = 0.01). Conclusion: Repeated HRS injections after trauma increased the viability of skin flap in rat degloving injury model by decreasing local tissue injury, due to its antioxidant, anti-inflammatory and angiogenic effects. | |
| dc.identifier.citation | Ergan Şahin, A., Karasoy Yeşilada, A., Yalçın, Ö., Güler, E. M., Erbek, H. ve Karabıyık, D. (2021). Hydrogen-rich saline reduces tissue injury and improves skin flap survival on a rat hindlimb degloving injury model. Journal of Plastic, Reconstructive and Aesthetic Surgery, 74(9), 2095-2103. https://dx.doi.org/10.1016/j.bjps.2020.12.045 | |
| dc.identifier.doi | 10.1016/j.bjps.2020.12.045 | |
| dc.identifier.endpage | 2103 | |
| dc.identifier.issn | 1748-6815 | |
| dc.identifier.issn | 1878-0539 | |
| dc.identifier.issue | 9 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.startpage | 2095 | |
| dc.identifier.uri | https://dx.doi.org/10.1016/j.bjps.2020.12.045 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/8440 | |
| dc.identifier.volume | 74 | |
| dc.identifier.wosquality | Q2 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Elsevier Science Ltd | |
| dc.relation.ispartof | Journal of Plastic, Reconstructive and Aesthetic Surgery | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/embargoedAccess | |
| dc.subject | Degloving Injury | |
| dc.subject | Flap | |
| dc.subject | Hydrogen-Rich Saline | |
| dc.subject | Ischemia/Reperfusion Injury | |
| dc.title | Hydrogen-rich saline reduces tissue injury and improves skin flap survival on a rat hindlimb degloving injury model | |
| dc.type | Article |
