Efficiency of double inversion recovery (DIR) sequence in the evaluation of supratentorial cortical lesions in multiple sclerosis

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dc.authorid0000-0002-0742-1305
dc.authorid0000-0003-0334-811X
dc.contributor.authorErtan, Gülhan
dc.contributor.authorArıcı Düz, Özge
dc.contributor.authorUlus, Sıla
dc.contributor.authorMetin, Barış
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:50Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:50Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.descriptionWOS: 000429001000004
dc.description.abstractThe aim of this study is to investigate if the three-dimensional (3D) double inversion recovery (DIR) sequence is superior compared to the 3D fluid-attenuated inversion-recovery (FLAIR) sequence in detecting intracortical, mixed, juxtacortical (JX), and deep grey matter (GM) lesions in multiple sclerosis (MS) patients. The correlation between intracortical lesion load and disability status was also investigated. Magnetic resonance imaging examinations of 24 patients (9 males, 15 females; mean age 34.4 +/- 12.0 (16-69) were retrospectively evaluated from our database. Lesions were counted and classified according to anatomic regions as intracortical, mixed, JX, and deep GM on the 3D DIR and FLAIR sequences. The incidence of lesions on the two sequences were identified and compared. The relationship between the number of lesions and type of MS, patient age, gender, duration of the disease, disability, the mean number of attacks per year and Expanded Disability Status Scale (EDSS) score was also investigated. More lesions were detected by the DIR sequence compared to the FLAIR sequence in all regions except for thalamus (11/12). The lesion detection superiority of DIR was statistically significant for intracortical lesions (p<0.001) and GM lesions (intracortical + mixed) (p<0.001). Lesion load of the JX area in the DIR sequence decreased as the disease duration (r=-0.444; p=0.030) and age (r=-0.473; p=0.020) increased. JX lesion load in the DIR sequence decreased as the number of attacks increased (r=-0.602; p=0.002). More mixed lesion load on the DIR sequence were found in cerebral atrophy group than in no cerebral atrophy group (p=0.026). EDSS score increased as the disease duration and number of attacks increased (p=0.003, p<0.001). There was no correlation between lesion location and EDSS score. The DIR sequence is superior to the FLAIR sequence in the detection of intracortical and GM lesions. Also, the mixed lesion load on the DIR sequence is correlated with cerebral atrophy.
dc.identifier.citationErtan, G., Arıcı Düz, Ö., Ulus, S. ve Metin, B. (2018). Efficiency of double inversion recovery (DIR) sequence in the evaluation of supratentorial cortical lesions in multiple sclerosis. Journal of Neuroquantology, 16(3), 23-29. https://dx.doi.org/10.14704/nq.2018.16.3.1179
dc.identifier.doi10.14704/nq.2018.16.3.1179
dc.identifier.endpage29
dc.identifier.issn1303-5150
dc.identifier.issue3
dc.identifier.scopusqualityQ4
dc.identifier.startpage23
dc.identifier.urihttps://dx.doi.org/10.14704/nq.2018.16.3.1179
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2085
dc.identifier.volume16
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAnka Publisher
dc.relation.ispartofNeuroquantologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMultiple Sclerosis
dc.subjectMagnetic Resonance Imaging (MRI)
dc.subjectDouble Inversion Recovery (DIR) Sequence
dc.subjectFluid Attenuated Inversion-recovery (FLAIR) Sequence
dc.subjectCortical Lesion
dc.titleEfficiency of double inversion recovery (DIR) sequence in the evaluation of supratentorial cortical lesions in multiple sclerosis
dc.typeArticle

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