Ocular surface and tear parameters in patients with chronic hepatitis c at initial stages of hepatic fibrosis

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dc.authorid0000-0001-9829-7268
dc.authorid0000-0001-5335-3860
dc.authorid0000-0001-8954-5055
dc.authorid0000-0002-5079-4713
dc.authorid0000-0002-2563-2149
dc.contributor.authorKaraman Erdur, Sevil
dc.contributor.authorKulaç Karadeniz, Derya
dc.contributor.authorKocabora, Mehmet Selim
dc.contributor.authorÖzsütçü, Mustafa
dc.contributor.authorGülkılık, İbrahim Gökhan
dc.contributor.authorDemirci, Göktuğ
dc.contributor.authorEliaçık, Mustafa
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:00Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:00Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000350136600012
dc.descriptionPubMed ID: 25503914
dc.description.abstractPurpose: The aim of this study was to evaluate changes in ocular surface and tear function parameters in chronic hepatitis C at initial stages of hepatic fibrosis. Methods: Thirty-one patients with biopsy-proven chronic hepatitis C and 31 age-and sex-matched healthy control subjects without systemic hepatitis C infection were examined with the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I, tear film break-up time, and scoring of ocular surface fluorescein and Rose Bengal staining using modified Oxford and van Bijsterveld scoring systems, respectively. Results: All ocular surface parameters, except OSDI and corneal staining scores, were significantly worse in hepatitis C group. The control group had greater OSDI scores than the hepatitis C group, but there was no statistically important difference. In subgroup analysis, progression of hepatic fibrosis was found to be correlated strongly with decreased Schirmer test I, increased OSDI, lid parallel conjunctival folds, conjunctival, and corneal staining scores. Conclusion: Patients with chronic hepatitis C were more likely to exhibit severe ocular surface damage and signs of dry eye.
dc.identifier.citationKaraman Erdur, S., Kulaç Karadeniz, D., Kocabora, M. S., Özsütçü, M., Gülkılık, İ. G., Demirci, G. ve Eliaçık, M. (2015). Ocular surface and tear parameters in patients with chronic hepatitis c at initial stages of hepatic fibrosis. Eye and Contact Lens, 41(2), 117-120. https://dx.doi.org/10.1097/ICL.0000000000000079
dc.identifier.doi10.1097/ICL.0000000000000079
dc.identifier.endpage120
dc.identifier.issn1542-2321
dc.identifier.issn1542-233X
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage117
dc.identifier.urihttps://dx.doi.org/10.1097/ICL.0000000000000079
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2522
dc.identifier.volume41
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams and Wilkins
dc.relation.ispartofEye and Contact Lensen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectTear Film
dc.subjectHepatitis C
dc.subjectDry Eye Disease
dc.subjectOcular Surface
dc.titleOcular surface and tear parameters in patients with chronic hepatitis c at initial stages of hepatic fibrosis
dc.typeArticle

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