Determination of antioxidant, anticancer, antidiabetic and antimicrobial activities of Turkish red pine (Pinus brutia Ten.) bark ultrasound-assisted extract as a functional food additive

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dc.authorid0000-0002-6816-8147
dc.authorid0000-0002-1423-0435
dc.contributor.authorErol, Kübra Feyza
dc.contributor.authorKutlu, Gözde
dc.contributor.authorTornuk, Fatih
dc.contributor.authorGüzel, Mustafa
dc.contributor.authorDönmez, İlhami Emrah
dc.date.accessioned2023-08-25T08:12:23Z
dc.date.available2023-08-25T08:12:23Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractTurkish red pine (Pinus brutia Ten.) is an important tree species that grows widely in Turkiye. In this study, Box-Behnken experimental design was created and optimised for ultrasound assisted extraction of bioactive components of Turkish red pine waste bark. Extraction yield, total phenolic content (TPC), total concentrated tannin (TCT), ferric reducing antioxidant power (FRAP), and 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) were determined at experimental points. As a result of the optimisation process, optimum parameter values were found at 34.8 8C temperature, 6.5 min time and 116.3 W ultrasonic power. Under optimum conditions, the extraction efficiency was 13.16%, TPC 103.09 mg GAE/g, TCT 13.29 mg CE/g, FRAP 602.14 mg TEAC/g , ABTS 624.51 mg TEAC/g activity results were obtained. The extracts obtained showed low in vitro toxicity against healthy cell lines (HEK-293, human embryonic kidney), proliferation of CaCo-2 (human colorectal adenocarcinoma) , MIA PaCa-2 (human pancreatic adenocarcinoma) cancer cells was significantly reduced. It was also determined that this extract has lower activity against Alzheimer's disease (AD)-associated AChE (acetylcholinesterase)-BChE (butyrylcholinesterase) than diabetes disease associated a-glucosidase and a-amylase. The extracts also showed significant antibacterial activity against Staphylococcus aureus, Bacillus cereus, Listeria mono-cytogenes, Salmonella Typhimurium, and Escherichia coli.
dc.description.sponsorship100/2000 Ph.D. scholarship program of the Council of Higher Education (CoHE) ; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TÜBİTAK)en_US
dc.identifier.citationErol, K. F., Kutlu, G., Tornuk, F., Güzel, M. ve Dönmez, İ. E. (2023). Determination of antioxidant, anticancer, antidiabetic and antimicrobial activities of Turkish red pine (Pinus brutia Ten.) bark ultrasound-assisted extract as a functional food additive. Acta Alimentaria, 52(1), 102-112. https://dx.doi.org/10.1556/066.2022.00197
dc.identifier.doi10.1556/066.2022.00197
dc.identifier.endpage112
dc.identifier.issn0139-3006
dc.identifier.issn1588-2535
dc.identifier.issue1
dc.identifier.startpage102
dc.identifier.urihttps://dx.doi.org/10.1556/066.2022.00197
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11362
dc.identifier.volume52
dc.identifier.wos001040496600010en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.institutionauthorErol, Kübra Feyza
dc.institutionauthorGüzel, Mustafa
dc.language.isoen
dc.publisherAkademiai Kiado Zrt.
dc.relation.ispartofActa Alimentariaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPinus Brutia Ten
dc.subjectUltrasonication
dc.subjectAntidiabetic
dc.subjectAnticancer Activity
dc.subjectFunctional Food Additive
dc.titleDetermination of antioxidant, anticancer, antidiabetic and antimicrobial activities of Turkish red pine (Pinus brutia Ten.) bark ultrasound-assisted extract as a functional food additive
dc.typeArticle

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