PD-L1 expression in immune cells is a favorable prognostic factor for nasopharyngeal carcinoma

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dc.contributor.authorŞahinli, Hayriye
dc.contributor.authorAkyürek, Nalan
dc.contributor.authorYılmaz, Mukaddes
dc.contributor.authorKandemir, Olcay
dc.contributor.authorOcak Duran, Ayşe
dc.contributor.authorKulaçoğlu, Sezer
dc.contributor.authorUçar, Gökhan
dc.contributor.authorAcar, Elif
dc.contributor.authorÖzet, Ahmet
dc.contributor.authorGümüş, Mahmut
dc.contributor.authorÇakmak Öksüzoğlu, Ömür Berna
dc.contributor.authorYıldırım Özdemir, Nuriye
dc.date.accessioned2021-04-05T12:59:07Z
dc.date.available2021-04-05T12:59:07Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Programmed death-ligand 1 (PD-L1) has been determined as a reliable prognostic factor for various malignancies. In this study, we aimed to determine the prognostic effect of PD-L1 expression in tumor-infiltrating immune cells (TIICs) of nasopharyngeal carcinoma (NPC) patients.Methods: Seventy patients diagnosed with non-metastatic NPC were included in the study. PD-L1 expression on immune cells was analyzed by immunohistochemical method. Patients were categorized into two groups according to the PD-L1 expression level in TIICs (level of PD-L1 staining ?5% positive vs <5% negative).Results: Median follow-up period was 34 months (range = 1 - 188). 1 and 2 years survival rate were found as 75% and 63% in PD-L1 negative TIICs group (47%), and 85% and 83% in PD-L1 positive TIICs group (53%), respectively. PD-L1 positivity in immune cells (ICs) was detected in 53% of the patients. The survival rate was found better in the PD- L1 positive group compared to the negative group (P = 0.049).Discussion: In conclusion, the survival rate was found significantly better in the PD-L1 positive TIICs group, compared to the negative group.
dc.identifier.citationŞahinli, H., Akyürek, N., Yılmaz, M., Kandemir, O., Ocak Duran, A., Kulaçoğlu, S. ... Yıldırım Özdemir, N. (2021). PD-L1 expression in immune cells is a favorable prognostic factor for nasopharyngeal carcinoma. Indian Journal of Cancer, 58(4), 561-566. https://dx.doi.org/10.4103/ijc.IJC_459_19
dc.identifier.doi10.4103/ijc.IJC_459_19
dc.identifier.endpage566
dc.identifier.issn0019-509X
dc.identifier.issn1998-4774
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage561
dc.identifier.urihttps://dx.doi.org/10.4103/ijc.IJC_459_19
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6696
dc.identifier.volume58
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIndian Cancer Society
dc.relation.ispartofIndian Journal of Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectNasopharyngeal Carcinoma
dc.subjectPrognosis
dc.subjectProgrammed Death Ligand-1
dc.titlePD-L1 expression in immune cells is a favorable prognostic factor for nasopharyngeal carcinoma
dc.typeArticle

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