Long-term efficacy of different doses of steroid in hospitalized COVID-19 patients: A prospective cohort study

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dc.authorid0000-0002-4091-6465
dc.contributor.authorKarakurt, Gökhan
dc.contributor.authorÜçgün, Hikmet
dc.contributor.authorAynacı, Engin
dc.contributor.authorDüger, Mustafa
dc.contributor.authorDemir, Şükrü Egemen
dc.date.accessioned2023-12-25T12:53:55Z
dc.date.available2023-12-25T12:53:55Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.description.abstractINTRODUCTION The aim of our study was to investigate the long-term effects of different doses of steroid therapy given in the acute period in hospitalized coronavirus disease 2019 (COVID-19) patients. METHODS A total of 78 patients who were followed up in the hospital due to COVID-19 pneumonia and were discharged from the hospital more than 3 months ago, were included in our study. The patients were divided into 3 groups according to the steroid doses they received. RESULTS The value of peak expiratory flow (PEF) was significantly lower in pulse-dose steroid group compared to high-dose steroid group (p=0.040). There was a significant difference in the values of carbon monoxide diffusion capacity (DLCO) and diffusion coefficient of alveolar volume (DLCO/VA) among all groups (p=0.027, p=0.048). The values of DLCO and DLCO/VA were significantly lower in the pulse-dose steroid group compared to the high-dose steroid group (p=0.022, p=0.049). The computed tomography (CT) score was significantly higher in the pulse-dose steroid group compared to both the nonsteroid group and high-dose steroid group (p=0.027, p=0.043). CONCLUSIONS Pulse-dose steroid therapy given in the acute period of COVID-19 pneumonia may negatively affect pulmonary function and recovery in the long-term. In addition, high-dose steroids were found to have a positive effect on pulmonary function compared to pulse-steroid therapy and nonsteroid therapy.
dc.identifier.citationKarakurt, G., Üçgün, H., Aynacı, E., Düger, M. ve Demir, Ş. E. (2023). Long-term efficacy of different doses of steroid in hospitalized COVID-19 patients: A prospective cohort study. Pneumon, 36(4). https://dx.doi.org/10.18332/pne/174604
dc.identifier.doi10.18332/pne/174604
dc.identifier.issn1105-848X
dc.identifier.issn1791-4914
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85179328818
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://dx.doi.org/10.18332/pne/174604
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12070
dc.identifier.volume36
dc.identifier.wos001118606300001en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorDüger, Mustafa
dc.language.isoen
dc.publisherEuropean Publishing
dc.relation.ispartofPneumonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectCOVID-19
dc.subjectDLCO
dc.subjectPulmonary Function
dc.subjectSteroid
dc.titleLong-term efficacy of different doses of steroid in hospitalized COVID-19 patients: A prospective cohort study
dc.typeArticle

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