The effect of rapamycin treatment on mouse ovarian follicle development in dehydroepiandrosterone-induced polycystic ovary syndrome mouse model

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dc.contributor.authorYıldırım, Ecem
dc.contributor.authorÖnel, Tuğçe
dc.contributor.authorAğuş, Sami
dc.contributor.authorGünalan, Elif
dc.contributor.authorYılmaz, Bayram
dc.contributor.authorAydın, Mehmet Şerif
dc.contributor.authorYaba, Aylin
dc.date.accessioned2025-10-28T06:52:35Z
dc.date.available2025-10-28T06:52:35Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractPolycystic ovary syndrome (PCOS) is a complex reproductive and endocrine disorder affecting 5-10% of women of reproductive age, but the pathophysiology of PCOS still remains unknown. Here, the aim of our study was to analyze the effects of rapamycin treatment that may regulate impaired hormonal levels and folliculogenesis in dehydroepiandrosterone (DHEA)-treated PCOS mouse. We hypothesized that rapamycin may ameliorate the negative effects of PCOS in DHEA-induced PCOS mouse model. The target of rapamycin (TOR) gene product is a serine/threonine kinase that has been implicated in the control of cell growth, proliferation and autophagy, and rapamycin is a potent inhibitor of mTORC1 pathway. In this study, for the first time, mTORC1 and activation products are presented at protein and mRNA levels after rapamycin treatment in DHEA-induced PCOS mouse ovary. We showed that rapamycin treatment may regulate follicular development, hormonal levels and provide ovulation in DHEA-induced PCOS mouse. Additionally, we assessed decreased primordial follicle reserve, increased number of primary and secondary follicles, corpus luteum structure forms again after 10 days of rapamycin treatment. This study presented here suggests rapamycin treatment regulates hormonal phenotype and folliculogenesis in the ovary and also mTOR signalling pathway in granulosa cells of DHEA-induced PCOS mouse ovary which may have potential to attenuate understanding the mechanism of dominant follicle selection and anovulatory infertility.
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu (TÜBİTAK)
dc.identifier.citationYıldırım, E., Önel, T., Ağuş, S., Günalan, E., Yılmaz, B., Aydın, M. Ş. ... Yaba, A. (2024). The effect of rapamycin treatment on mouse ovarian follicle development in dehydroepiandrosterone-induced polycystic ovary syndrome mouse model. Zygote, 32(5), 386-395. http://dx.doi.org/10.1017/S0967199424000388
dc.identifier.doi10.1017/S0967199424000388
dc.identifier.endpage395
dc.identifier.issn0967-1994
dc.identifier.issn1469-8730
dc.identifier.issue5
dc.identifier.pmid39498504
dc.identifier.scopus2-s2.0-85209707773
dc.identifier.scopusqualityQ4
dc.identifier.startpage386
dc.identifier.urihttp://dx.doi.org/10.1017/S0967199424000388
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13150
dc.identifier.volume32
dc.identifier.wosWOS:001351978900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAydın, Mehmet Şerif
dc.institutionauthorid0000-0002-6393-1465
dc.language.isoen
dc.relation.ecinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/215S328
dc.relation.ispartofZygote
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDehidroepiandrostenedion
dc.subjectFolliculogenesis
dc.subjectMammalian Target of Rapamycin
dc.subjectOvulation
dc.subjectPolycystic Ovary Syndrome
dc.subjectRapamycin
dc.titleThe effect of rapamycin treatment on mouse ovarian follicle development in dehydroepiandrosterone-induced polycystic ovary syndrome mouse model
dc.typeArticle

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