Waning immunity to inactive SARS-CoV-2 vaccine in healthcare workers: Booster required

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dc.authorid0000-0001-7275-8724
dc.contributor.authorBalkan, İlker İnanç
dc.contributor.authorDinç, Harika Öykü
dc.contributor.authorCan, Günay
dc.contributor.authorKaraali, Rıdvan
dc.contributor.authorÖzbey, Doğukan
dc.contributor.authorÇağlar, Bilge
dc.contributor.authorBeytur, Ayşe Nur
dc.contributor.authorKeskin, Elif
dc.contributor.authorBudak, Beyhan
dc.contributor.authorAydoğan, Okan
dc.contributor.authorMete, Bilgül
dc.contributor.authorErgin, Sevgi
dc.contributor.authorKocazeybek, Bekir
dc.contributor.authorSaltoğlu, Neşe
dc.date.accessioned2023-02-23T06:55:15Z
dc.date.available2023-02-23T06:55:15Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractAims Despite high vaccination rates, increasing case numbers continue to be reported with the identification of new variants of concern, and the issue of durability of the vaccine-induced immune response remains hot topic. Real-life data regarding time-dependent immunogenicity of inactivated COVID-19 vaccines are scarce. We aimed to investigate the changes in the antibody at the different times after the second dose of the CoronaVac vaccine. Methods The study included 175 HCWs vaccinated with inactive CoronaVac (Sinovac Life Sciences, China) SARS-CoV-2 vaccine in two doses. Anti-spike/RBD IgG levels were measured first, third, and sixth months after the second dose. Chemiluminescent microparticle immunoassay (IgG II Quant test, Abbott, USA), which is 100% compatible with plaque reduction neutralization test, was used. Results Mean age of the participants was 38 +/- 11.23 years (range between 22 and 66) of whom 119 (63.9%) were female, and 56 (32%) were male. Dramatic reductions were demonstrated in median antibody levels particularly in the infection-naive group, comprising 138 HCWs compared to those with prior history of COVID-19 infection (n = 37) (p < 0.001). There was no difference between the two groups in terms of age, gender, blood groups, BMI, and comorbid diseases. Conclusions While antibody positivity remained above 90% in the 6th month after two doses of inactivated vaccine in HCWs, the median titers of neutralizing antibodies decreased rapidly. The decrease was more rapid and significant in those with no history of prior COVID-19 infection. In this critical phase of the pandemic, where we are facing the dominance of the Omicron variant after Delta, booster doses have become vital.
dc.description.sponsorshipIU-Cerrahpasa Scientific Research Projects Uniten_US
dc.identifier.citationBalkan, İ. İ., Dinç, H. Ö., Can, G., Karaali, R., Özbey, D., Çağlar, B. ... Saltoğlu, N. (2023). Waning immunity to inactive SARS-CoV-2 vaccine in healthcare workers: Booster required. Irish Journal of Medical Science, 192(1), 19-25. https://doi.org/10.1007/s11845-022-02984-1
dc.identifier.doi10.1007/s11845-022-02984-1
dc.identifier.endpage25
dc.identifier.issn0021-1265
dc.identifier.issn1863-4362
dc.identifier.issue1
dc.identifier.pmid35344137
dc.identifier.scopus2-s2.0-85127245455
dc.identifier.scopusqualityQ3
dc.identifier.startpage19
dc.identifier.urihttps://doi.org/10.1007/s11845-022-02984-1
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10512
dc.identifier.volume192
dc.identifier.wos000773803700001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAydoğan, Okan
dc.language.isoen
dc.publisherSpringer London Ltd
dc.relation.ispartofIrish Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOVID-19
dc.subjectInactive Vaccine
dc.subjectNeutralizing Antibody
dc.subjectSinovac
dc.titleWaning immunity to inactive SARS-CoV-2 vaccine in healthcare workers: Booster required
dc.typeArticle

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