Myocardial injury biomarkers after radiofrequency catheter and cryoballoon ablation for atrial fibrillation and their impact on recurrence

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dc.authorid0000-0003-1919-3183
dc.authorid0000-0001-5825-8627
dc.authorid0000-0001-9975-5507
dc.authorid0000-0003-0230-6575
dc.authorid0000-0002-4607-5724
dc.contributor.authorKızılırmak, Filiz
dc.contributor.authorGökdeniz, Tayyar
dc.contributor.authorGüneş, Hacı Murat
dc.contributor.authorDemir, Gültekin Günhan
dc.contributor.authorÇakal, Beytullah
dc.contributor.authorBabur Güler, Gamze
dc.contributor.authorGüler, Ekrem
dc.contributor.authorOlgun, Fatih Erkam
dc.contributor.authorKılıçaslan, Fethi
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:35Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:35Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000395790600005
dc.descriptionPubMed ID: 27221959
dc.description.abstractBackground: Myocardial injury induced by catheter ablation (CA) for atrial fibrillation (AF) leads to elevated biomarker levels. Aim: This prospective study examined levels of myocardial injury biomarkers (creatinine kinase [CK], myocardial bound for CK [CK-MB], and troponin I [TnI]) and their impact on AF recurrence following two different ablation strategies, namely: cryoballoon ablation (CBA) and radiofrequency ablation (RFA). We also aimed to evaluate the relationship between AF recurrence after CA and other clinical, echocardiographic and procedural parameters. Methods: We enrolled 98 patients with AF, 21% of whom had persistent AF and 79% had paroxysmal AF. 58% of patients underwent CBA, and 42% underwent RFA. CK, CK-MB, and TnI levels were measured before and 6 h after the procedure. Patients had follow-up visits three, six, and nine months after the index procedure. Biomarker levels were compared between the patients with and without AF recurrence. Results: Post-ablation CK (postCK), post-ablation CK-MB (postCKMB), and post-ablation TnI (postTnI) levels were significantly high in the CBA and RFA groups (p < 0.001 for all). TnI elevation (DTnI) was correlated with age (p = 0.033) and median temperature reached during ablation (p < 0.005) in the CBA group, while it was correlated with application time in the RFA group (p < 0.001). Multivariate analysis in the CBA group revealed age and left atrium diameter as positive independent predictors (p = 0.029 and p = 0.046), and DTnI as a negative independent predictor for AF recurrence (p = 0.001). Elevated cardiac biomarkers were not associated with AF recurrence in the RFA group (p > 0.05). Conclusions: The levels of all cardiac biomarkers were elevated after CBA and RFA. Elevated TnI levels after CBA were independent negative predictors of AF recurrence. Measurement of TnI levels after CBA may be useful for the prediction of better clinical outcome.
dc.identifier.citationKızılırmak, F., Gökdeniz, T., Güneş, H. M., Demir, G. G., Çakal, B., Babur Güler, G. ... Kılıçaslan, F. (2017). Myocardial injury biomarkers after radiofrequency catheter and cryoballoon ablation for atrial fibrillation and their impact on recurrence. Kardiologia Polska, 75(2), 126-134. https://dx.doi.org/10.5603/KP.a2016.0089
dc.identifier.doi10.5603/KP.a2016.0089
dc.identifier.endpage134
dc.identifier.issn0022-9032
dc.identifier.issn1897-4279
dc.identifier.issue2
dc.identifier.scopusqualityQ3
dc.identifier.startpage126
dc.identifier.urihttps://dx.doi.org/10.5603/KP.a2016.0089
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3354
dc.identifier.volume75
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVia Medica
dc.relation.ispartofKardiologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCatheter Ablation
dc.subjectAtrial Fibrillation
dc.subjectMyocardial Injury Biomarkers
dc.titleMyocardial injury biomarkers after radiofrequency catheter and cryoballoon ablation for atrial fibrillation and their impact on recurrence
dc.typeArticle

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