Correlation of diffusion weighted MR imaging and ADC values of hepatic metastasis of gastrointestinal stromal and gastroenteropancreatic neuroendocrine tumors
| dc.contributor.author | Aydın, Hasan | |
| dc.contributor.author | Metin, Melike Ruşen | |
| dc.contributor.author | Kızılgöz, Volkan | |
| dc.date.accessioned | 2023-12-18T09:40:21Z | |
| dc.date.available | 2023-12-18T09:40:21Z | |
| dc.date.issued | 2024 | |
| dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı | |
| dc.description.abstract | Background: DWI and ADC-mapping was performed to analyze hepatic metastasis of GIST, GEP-NET. Objective: The objective of this study is to present hepatic metastasis of GIST and GEP-NET with Diffusion weighted MR imaging(DWI) and the Apparent diffusion coefficients (ADC) values of masses. Methods: 18 GIST patients and 8 GEP-NET patients were examined retrospectively. 11 males and 6 females were present in GIST group, 7 males to 5 females were involved in GEP-NET group. 18 primary GIST and 10 hepatic metastasis of GIST, 8 original GEP-NET and 19 hepatic metastasis of GEP-NET; total 55 GIST and GEP-NET masses were analysed by ADC mapping. MR images were acquired by 1,5 T MR units (32 mT/min gradient strength-Achieva; Philips Healthcare, Best, Netherlands and 32 channel GE Signa GE-Wisconsin-USA); by using a 4-8 channel standard phased-array torso XL coil, all images were evaluated by an Abdominal MRI experienced radiologist. DWI was performed in the transverse plane by using spin-echo-planar imaging sequence. Results: No statistical differences were observed between GIST and GEP-NET patients according to age and gender variations. No significant statistical differences were observed according to the diameters and ADC values of GIST and GEP-NET patients. A significant statistical difference was observed between GIST and GEP-NET groups in terms of size of liver metastasis which was significantly higher in GIST patients. All three groups (GIST_Hep. MET, GEP-NET_Liver_Met and normal) were statistically differed according to ADC values. With the ROC curve analysis: Hepatic metastasis of GIST(n=10) and normal liver (n:47) had cut-off value for ADC: 0.925 under AUC: 0.939 with regard to ADC values and regarded 89.4% Sensitivity, 100% Specificity, 100% PPV and 66.7% PPV. ROC curve of GEP NET_ Hepatic metastasis (n=19) group and normal liver (n:47) group presented cut-off value for ADC: 0.860 under AUC: 0.967 correlated to ADC values with 93.6% sensitivity, 89.5% specificity, 95.7% PPV and 85% PPV. Conclusion: High cellular tumors resulted from liver metastasis of GIST and GEP-NET’s, and a positive correlation was observed between ADC values and cellularity/differentiation ratios of metastatic masses. | |
| dc.identifier.citation | Aydın, H., Metin, M. R. ve Kızılgöz, V. (2024). Correlation of diffusion weighted MR imaging and ADC values of hepatic metastasis of gastrointestinal stromal and gastroenteropancreatic neuroendocrine tumors. Current Medical Imaging, 20. https://dx.doi.org/10.2174/1573405620666230522151427 | |
| dc.identifier.doi | 10.2174/1573405620666230522151427 | |
| dc.identifier.issn | 1573-4056 | |
| dc.identifier.issn | 1875-6603 | |
| dc.identifier.pmid | 37272460 | |
| dc.identifier.scopus | 2-s2.0-85178310374 | |
| dc.identifier.scopusquality | Q3 | |
| dc.identifier.uri | https://dx.doi.org/10.2174/1573405620666230522151427 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/12020 | |
| dc.identifier.volume | 20 | |
| dc.identifier.wos | WOS:001307790600001 | |
| dc.identifier.wosquality | Q3 | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.institutionauthor | Metin, Melike Ruşen | |
| dc.language.iso | en | |
| dc.publisher | Bentham Science Publishers | |
| dc.relation.ispartof | Current Medical Imaging | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | Attribution 4.0 International | * |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/legalcode | * |
| dc.subject | Diffusion | |
| dc.subject | GIST | |
| dc.subject | Hepatic | |
| dc.subject | Imaging | |
| dc.subject | Metastasis | |
| dc.subject | MR | |
| dc.title | Correlation of diffusion weighted MR imaging and ADC values of hepatic metastasis of gastrointestinal stromal and gastroenteropancreatic neuroendocrine tumors | |
| dc.type | Article |
