Serrate RNA effector molecule (SRRT) is associated with prostate cancer progression and is a predictor of poor prognosis in lethal prostate cancer

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dc.authorid0000-0001-6657-9738
dc.contributor.authorGamallat, Yaser
dc.contributor.authorChoudhry, Muhammad
dc.contributor.authorLi, Qiaowang
dc.contributor.authorRokne, Jon George
dc.contributor.authorAlhajj, Reda
dc.contributor.authorAbdelsalam, Ramy
dc.contributor.authorGhosh, Sunita
dc.contributor.authorArbet, Jaron
dc.contributor.authorBoutros, Paul C.
dc.contributor.authorBismar, Tarek A.
dc.date.accessioned2023-06-09T10:49:14Z
dc.date.available2023-06-09T10:49:14Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Bilgisayar Mühendisliği Bölümü
dc.description.abstractArsenite-resistance protein 2, also known as serrate RNA effector molecule (ARS2/SRRT), is known to be involved in cellular proliferation and tumorigenicity. However, its role in prostate cancer (PCa) has not yet been established. We investigated the potential role of SRRT in 496 prostate samples including benign, incidental, advanced, and castrate-resistant patients treated by androgen deprivation therapy (ADT). We also explored the association of SRRT with common genetic aberrations in lethal PCa using immunohistochemistry (IHC) and performed a detailed analysis of SRRT expression using The Cancer Genome Atlas (TCGA PRAD) by utilizing RNA-seq, clinical information (pathological T category and pathological Gleason score). Our findings indicated that high SRRT expression was significantly associated with poor overall survival (OS) and cause-specific survival (CSS). SRRT expression was also significantly associated with common genomic aberrations in lethal PCa such as PTEN loss, ERG gain, mutant TP53, or ATM. Furthermore, TCGA PRAD data revealed that high SRRT mRNA expression was significantly associated with higher Gleason scores, PSA levels, and T pathological categories. Gene set enrichment analysis (GSEA) of RNAseq data from the TCGA PRAD cohort indicated that SRRT may play a potential role in regulating the expression of genes involved in prostate cancer aggressiveness. Conclusion: The current data identify the SRRT's potential role as a prognostic for lethal PCa, and further research is required to investigate its potential as a therapeutic target.
dc.description.sponsorshipProstate Cancer Foundation Young Investigator Award ; Prostate Cancer Canada ; Canadian Cancer Society (CCS)en_US
dc.identifier.citationGamallat, Y., Choudhry, M., Li, Q., Rokne, J. G., Alhajj, R. ve Abdelsalam, R. (2023). Serrate RNA effector molecule (SRRT) is associated with prostate cancer progression and is a predictor of poor prognosis in lethal prostate cancer. Cancers, 15(10). https://doi.org/10.3390/cancers15102867
dc.identifier.doi10.3390/cancers15102867
dc.identifier.issn2072-6694
dc.identifier.issue10
dc.identifier.scopus2-s2.0-85160718767
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/cancers15102867
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11057
dc.identifier.volume15
dc.identifier.wos000997202200001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAlhajj, Reda
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofCancersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectARS2/SRRT (Arsenite-Resistance Protein 2/Serrate RNA Effector Molecule)
dc.subjectERG
dc.subjectPTEN
dc.subjectTP53
dc.subjectATM
dc.subjectLethal Prostate Cancer
dc.titleSerrate RNA effector molecule (SRRT) is associated with prostate cancer progression and is a predictor of poor prognosis in lethal prostate cancer
dc.typeArticle

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