The role of circadian rhythm proteins rev-erbα and β in the development of neuronal injury after traumatic brain injury

Basit Öğe Kaydı
dc.contributor.authorPençe, Mahmud Esad
dc.contributor.authorDoğan, Enes
dc.contributor.authorKoç, Halil İbrahim
dc.contributor.authorBayraktaroğlu, Çiğdem
dc.contributor.authorAltunay, Serdar
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorBeker, Mustafa Çağlar
dc.date.accessioned2025-12-10T08:33:40Z
dc.date.available2025-12-10T08:33:40Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractBackground/aim: Circadian rhythm proteins (CRPs) play critical roles in both physiological and pathophysiological conditions, including neurodegenerative disorders. As members of CRPs, the nuclear receptors Rev-Erbα/β regulate circadian rhythm particularly by inhibiting Bmal1 protein and are involved in the neuroinflammation and cell death processes. However, their roles in the development of neuronal injury after traumatic brain injury (TBI) were largely unexplored, and so were investigated in the present study. Materials and methods: For the induction of TBI, animals were subjected to the cryogenic model of TBI, which is a commonly used animal model and shares essential similarities with cerebral ischemia in terms of pathophysiological cascades. To assess the impact of Rev-Erb proteins on TBI, both Rev-Erbα and Rev-Erbβ proteins were activated or deactivated, and their expression profiles were determined by western blot analyses. Infarct volume and brain swelling were analyzed by cresyl violet staining. Blood–brain barrier (BBB) permeability was analyzed by immunoglobulin G extravasation. Neuronal survival was analyzed by NeuN immunohistochemistry. Results: Our observations indicate that Rev-Erbβ significantly reduced brain injury after TBI, which was reversed by inhibiting this protein. Not activation but the inhibition of both Rev-Erb proteins increased brain swelling significantly. In addition, both Rev-Erbα and Rev-Erbβ improved BBB permeability and neuronal survival significantly, which were reversed by their inhibitions. Conclusion: Our results show that Rev-Erbα and particularly Rev-Erbβ play significant roles in the development of neuronal injury after TBI. Our findings suggest that Rev-Erb proteins would be a potential therapeutic target for the treatment of neurodegenerative diseases.
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) ; Turkish Academy of Sciences
dc.identifier.citationPençe, M. E., Doğan, E., Koç, H. İ., Bayraktaroğlu, Ç., Altunay, S., Kılıç, E. ... Beker, M. Ç. (2024). The role of circadian rhythm proteins rev-erbα and β in the development of neuronal injury after traumatic brain injury. Turkish Journal of Medical Sciences, 54(6), 1409-1418. http://dx.doi.org/10.55730/1300-0144.5924
dc.identifier.doi10.55730/1300-0144.5924
dc.identifier.endpage1418
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6
dc.identifier.pmid39734357
dc.identifier.scopus2-s2.0-85212305756
dc.identifier.scopusqualityQ2
dc.identifier.startpage1409
dc.identifier.urihttp://dx.doi.org/10.55730/1300-0144.5924
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13316
dc.identifier.volume54
dc.identifier.wosWOS:001429214400027
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorPençe, Mahmud Esad
dc.institutionauthorDoğan, Enes
dc.institutionauthorKoç, Halil İbrahim
dc.institutionauthorBayraktaroğlu, Çiğdem
dc.institutionauthorAltunay, Serdar
dc.institutionauthorBeker, Mustafa Çağlar
dc.institutionauthorid0000-0002-8411-3138
dc.institutionauthorid0009-0009-3039-8826
dc.institutionauthorid0000-0003-2562-1068
dc.institutionauthorid0000-0002-7318-4053
dc.institutionauthorid0000-0002-4051-2559
dc.institutionauthorid0000-0002-9476-8488
dc.language.isoen
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/121S420
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/219S913
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCircadian Rhythm Proteins
dc.subjectNeuronal Survival
dc.subjectRev-Erb
dc.subjectTraumatic Brain Injury
dc.titleThe role of circadian rhythm proteins rev-erbα and β in the development of neuronal injury after traumatic brain injury
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Pençe-Mahmud Esad-2024.pdf
Boyut:
1.49 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu