The susceptibility to autoxidation of erythrocytes in diabetic mice: Effects of melatonin and pentoxifylline

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dc.authorid0000-0002-8084-7855
dc.contributor.authorŞekeroğlu, Mehmet Ramazan
dc.contributor.authorHuyut, Zübeyir
dc.contributor.authorÇokluk, Erdem
dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorAlp, Hamit Hakan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:25Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:25Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.descriptionWOS: 000417915400004
dc.description.abstractOxidative stress had a great importance in development of complications in diabetes. We investigated effects of melatonin and pentoxifylline in diabetic mice. Swiss albino mice (n=40) were divided into four groups: alloxan-induced diabetes mellitus (DM), alloxan-induced diabetes with melatonin supplementation (DM+MLT), alloxan-induced diabetes with pentoxifylline supplementation (DM+PTX), and control. Glutathione-peroxidase (GSH-Px) activity, malondialdehyde (MDA) and reduced glutathione (GSH) levels, and susceptibility to oxidation of erythrocytes were measured. MDA levels were higher than control in the DM and DM+MLT. The DM had more MDA level than the DM+MLT and DM+PTX (P<0.001). After in vitro oxidation, MDA levels of all groups were found higher than the control. However, they were significantly lower than the DM in DM+PTX and DM+MLT (P<0.001). Although GSH levels of the DM and DM+PTX were less than the control, GSH-Px activity of the DM was lower than the control and DM+PTX (P<0.05). We suggest that there is increased oxidative stress and compromised antioxidant status of erythrocytes in diabetes; however, it can be effectively prevented by melatonin or pentoxifylline supplementation.
dc.identifier.citationŞekeroğlu, M. R., Huyut, Z., Çokluk, E., Özbek, H. ve Alp, H. H. (2017). The susceptibility to autoxidation of erythrocytes in diabetic mice: Effects of melatonin and pentoxifylline. Journal of Biochemical and Molecular Toxicology, 31(12). https://dx.doi.org/10.1002/jbt.21976
dc.identifier.doi10.1002/jbt.21976
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue12
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1002/jbt.21976
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2972
dc.identifier.volume31
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAntioxidant Enzymes
dc.subjectDiabetes
dc.subjectMelatonin
dc.subjectPentoxifylline
dc.subjectRBC
dc.titleThe susceptibility to autoxidation of erythrocytes in diabetic mice: Effects of melatonin and pentoxifylline
dc.typeArticle

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