Charlson comorbidity index (CCI) in diffuse large B-cell lymphoma: A new approach in a multicenter study

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dc.authorid0000-0002-3385-8359
dc.contributor.authorEren, Rafet
dc.contributor.authorSerin, İstemi
dc.contributor.authorAtak, Süheyla
dc.contributor.authorPirdal, Betül Zehra
dc.contributor.authorNizam, Nihan
dc.contributor.authorGemici, Aliihsan
dc.contributor.authorAydın, Demet
dc.contributor.authorDemirel, Naciye
dc.contributor.authorDoğan, Esma Evrim
dc.contributor.authorYokuş, Osman
dc.date.accessioned2023-09-20T11:19:20Z
dc.date.available2023-09-20T11:19:20Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractPurpose: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of adult lymphomas. The incidence of DLBCL increases with age and has a fairly rapid fatal course without treatment. Patients often have difficulty tolerating standard chemotherapy regimens due to their comorbidities. Charlson Comorbidity Index (CCI), which is calculated by considering 19 different comorbidities, was developed in 1987 and is widely used for mortality prediction in cancer patients. Literature data on CCI and hematological malignancies are limited. Main aim in this study is to evaluate the effectiveness of CCI and compare to the International Prognostic Index (IPI) scoring system in the DLBCL patient group. Methods: A total of 170 patients diagnosed with DLBCL between 1.1.2002- 1.12.2020 were included in the study. Statistical analyzes were performed among patients whose IPI and CCI scores were recorded by considering baseline data. Results: The median age of patients was 58 (range: 17–84). Thirty-five (20.6%) patients had stage III and 76 (44.7%) had stage IV disease. When the CCI, IPI and ECOG scores were compared with the mortality status of the patients as a reference, AUCs were resulted as 0.628 (95% CI: 0.506–0.749), 0.563 (95% CI: 0.484–0.639) and 0.672 (95% CI: 0.596–0.743), respectively. There was no significant difference between the ROC curves of CCI, IPI and ECOG scores. Patients with a CCI score of ? 4 had shorter OS comperad to those with a score of < 4. Conclusion: Rather than claiming that CCI is superior to IPI, ECOG or another scoring system in a single-center patient population, it should be stated that CCI is also an effective scoring system in patients diagnosed with DLBCL.
dc.identifier.citationEren, R., Serin, İ., Atak, S., Pirdal, B. Z., Nizam, N., Gemici, A. ... Yokuş, O. (2023). Charlson comorbidity index (CCI) in diffuse large B-cell lymphoma: A new approach in a multicenter study. Indian Journal of Hematology and Blood Transfusion, 39(2), 191-199. https://doi.org/10.1007/s12288-022-01567-5
dc.identifier.doi10.1007/s12288-022-01567-5
dc.identifier.endpage199
dc.identifier.issn0971-4502
dc.identifier.issn0974-0449
dc.identifier.issue2
dc.identifier.pmid36186233
dc.identifier.scopus2-s2.0-85139131507
dc.identifier.scopusqualityQ3
dc.identifier.startpage191
dc.identifier.urihttps://doi.org/10.1007/s12288-022-01567-5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11470
dc.identifier.volume39
dc.identifier.wos000862902900002en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGemici, Aliihsan
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofIndian Journal of Hematology and Blood Transfusionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiffuse Large B-Cell Lymphoma
dc.subjectCharlson Comorbidity Index
dc.subjectPrognosis
dc.subjectEfficacy
dc.titleCharlson comorbidity index (CCI) in diffuse large B-cell lymphoma: A new approach in a multicenter study
dc.typeArticle

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