Kisspeptin levels in idiopathic hypogonadotropic hypogonadism diagnosed male patients and its relation with glucose-insulin dynamic

Basit Öğe Kaydı
dc.authorid0000-0002-3636-3853
dc.contributor.authorÖztin, Hasan
dc.contributor.authorÇagıltay, Eylem
dc.contributor.authorÇağlayan, Sinan
dc.contributor.authorKaplan, Mustafa
dc.contributor.authorAkpak, Yaşam Kemal
dc.contributor.authorKaraca, Nilay
dc.contributor.authorTiğlioğlu, Mesut
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:08Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:08Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000390162300014
dc.descriptionPubMed ID: 27616469
dc.description.abstractMale hypogonadism is defined as the deficiency of testosterone or sperm production synthesized by testicles or the deficiency of both. The reasons for hypogonadism may be primary, meaning testicular or secondary, meaning hypothalamohypophyseal. In hypogonadotropic hypogonadism (HH), there is indeficiency in gonadotropic hormones due to hypothalamic or hypophyseal reasons. Gonadotropin-releasing hormone (GnRH) is an important stimulant in releasing follicular stimulant hormone (FSH), mainly luteinizing hormone (LH). GnRH omitted is under the effect of many hormonal or stimulating factors. Kisspeptin is present in many places of the body, mostly in hypothalamic anteroventral periventricular nucleus and arcuate nucleus. Kisspeptin has a suppressor effect on the metastasis of many tumors such as breast cancer and malign melanoma metastases, and is called "metastin'' for this reason. Kisspeptin is a strong stimulant of GnRH. In idiopathic hypogonadotropic hypogonadism (IHH) etiology, there is gonadotropic hormone release indeficiency which cannot be clearly described. A total of 30 male hypogonatropic hypogonadism diagnosed patients over 30 years of age who have applied to Haydarpasa Education Hospital Endocrinology and Metabolic Diseases Service were included in the study. Compared to the control group, the effect of kisspeptin on male patients with hypogonatropic hypogonadism and on insulin resistance developing in hypogonadism patients was investigated in our study. A statistically significant difference was detected between average kisspeptin measurements of the groups (p < 0.01). Kisspeptin measurement of the cases in the patient group were detected significantly high. No statistically significant relation was detected among kisspeptin and LH/FSH levels. Although a positive low relation was detected between kisspeptin measurements of patient group cases and homeostasis model assessment of insulin resistance (HOMA-IR) measurements, this relation was statistically insignificant. When the patient and control groups were compared for HOMA-IR, no statistically significant difference was detected. The reason for high kisspeptin levels in the patient group compared to the control group makes us consider that there may be a GPR54 resistance or GnRH neuronal transfer pathway defect. When patients and control groups were compared for HOMA-IR, the difference was not statistically significant. It is considered that kisspeptin is one of the reasons for hypogonatropic hypogonadism and has less effect on insulin resistance.
dc.identifier.citationÖztin, H., Çagıltay, E., Çağlayan, S., Kaplan, M., Akpak, Y. K., Karaca, N. ... Tiğlioğlu, M. (2016). Kisspeptin levels in idiopathic hypogonadotropic hypogonadism diagnosed male patients and its relation with glucose-insulin dynamic. Gynecologıcal Endocrinology, 32(12), 991-994. https://dx.doi.org/10.1080/09513590.2016.1214258
dc.identifier.doi10.1080/09513590.2016.1214258
dc.identifier.endpage994
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue12
dc.identifier.scopusqualityQ2
dc.identifier.startpage991
dc.identifier.urihttps://dx.doi.org/10.1080/09513590.2016.1214258
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2590
dc.identifier.volume32
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofGynecologıcal Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGlucose
dc.subjectIdiopathic Hypogonadotropic Hypogonadism
dc.subjectInsulin
dc.subjectInsulin Resistance
dc.subjectKisspeptin
dc.titleKisspeptin levels in idiopathic hypogonadotropic hypogonadism diagnosed male patients and its relation with glucose-insulin dynamic
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Caglayan-Sinan 2016.pdf
Boyut:
366.03 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu