Quercus pyrenaica honeydew honey with high phenolic contents cause dna damage, apoptosis, and cell death through generation of reactive oxygen species in gastric adenocarcinoma cells

Basit Öğe Kaydı
dc.authorid0000-0003-4568-4234
dc.contributor.authorKoçyiğit, Abdurrahman
dc.contributor.authorAydoğdu, Gökhan
dc.contributor.authorBalkan, Ezgi
dc.contributor.authorYenigün, Vildan Betül
dc.contributor.authorGüler, Eray Metin
dc.contributor.authorBulut, Huri
dc.contributor.authorKoktaşoğlu, Fatmanur
dc.contributor.authorGören, Ahmet Ceyhan
dc.contributor.authorAtayoğlu, Ali Timuçin
dc.date.accessioned2019-12-27T06:59:21Z
dc.date.available2019-12-27T06:59:21Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalı
dc.description.abstractMany studies have shown that honey with high phenolic contents prevents cancer formation. Furthermore, recent studies have demonstrated that honey can be used for the treatment of cancer as well as cancer prevention. Antineoplastic effects of honey are often associated with their antioxidant phenolic contents. However, very few studies have dealt with the association of phenolic contents of honeys in terms of antiproliferative effects. The aim of this study was, therefore, to elucidate the cytotoxic, genotoxic, apoptotic, and reactive oxygen species (ROS) generating effects of honey samples on the basis of their phenolic and flavonoid contents. Fourteen different honey varieties were collected from various parts of Turkey, and their characteristics regarding total phenols, flavonoids, and antioxidant contents were determined to test their effects on gastric cancer cells (AGS). For convenience, 2 honey varieties were selected, namely, Ida Mountains Quercus pyrenaica honeydew honey (QPHH-IM) having the highest phenolic and antioxidant content and Canakkale multifloral honey (MFH-C) with the lowest phenolic and antioxidant content. Levels of 11 different phenolic compounds in QPHH-IM and MFH-C samples were determined by LC-MS/MS. AGS cells were incubated with different concentrations of QPHH-IM and MFH-C for 24 hours, then the cell viability, DNA damage, apoptosis, and generation of ROS were determined. We found that QPHH-IM had more cytotoxic, genotoxic, and apoptotic effects than that of MFH-C. We think that these effects are probably related to pro-oxidant activities due to the high phenolic contents present. Therefore, further research on high-phenolic honey may contribute to the future development of cancer therapeutics.
dc.identifier.citationKoçyiğit, A., Aydoğdu, G., Balkan, E., Yenigün, V. B., Güler, E. M., Bulut, H. ... Atayoğlu, A. T. (2019). Quercus pyrenaica honeydew honey with high phenolic contents cause dna damage, apoptosis, and cell death through generation of reactive oxygen species in gastric adenocarcinoma cells. Integrative Cancer Therapies, 18, 1-12. https://doi.org/10.1177/1534735419876334
dc.identifier.doi10.1177/1534735419876334
dc.identifier.endpage12
dc.identifier.issn1534-7354
dc.identifier.issn1552-695X
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1177/1534735419876334
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4756
dc.identifier.volume12
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSAGE
dc.relation.ispartofIntegrative Cancer Therapiesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-NoDerivs 4.0 United States*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/us/*
dc.subjectQuercus Pyrenaica
dc.subjectHoney
dc.subjectGastric Carcinoma
dc.subjectApoptosis
dc.subjectDNA Damage
dc.subjectReactive Oxygen Species
dc.subjectApitherapy
dc.titleQuercus pyrenaica honeydew honey with high phenolic contents cause dna damage, apoptosis, and cell death through generation of reactive oxygen species in gastric adenocarcinoma cells
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
atayoglu-ali-timucin(2019).pdf
Boyut:
614.87 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu