Low serum insulin like growth factor - 1 in patients with stress urinary incontinence

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dc.authorid0000-0001-5254-2563
dc.contributor.authorÖzbek, Emin
dc.contributor.authorÖtünçtemur, Alper
dc.contributor.authorŞahin, Süleyman
dc.contributor.authorÖzcan, Levent
dc.contributor.authorDursun, Murat
dc.contributor.authorPolat, Emrecan
dc.contributor.authorTülübaş, Feti
dc.contributor.authorÇekmen, Mustafa
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:29Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:29Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.descriptionWOS: 000391024000022
dc.descriptionPubMed ID: 27564291
dc.description.abstractObjective: SUI, involuntary loss of urine, occurs when intra abdominal pressure exceeds urethral pressure in women. Recent animal study has shown that there are therapeutic effects of Insulin-like growth factors (IGF-1) on stress urinary incontinence in rats with simulated childbirth trauma. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues and stimulates fibroblast proliferation and enhances collagen synthesis. The purpose of the current study was to determine the association between IGF-1 levels and SUI. Materials and Methods: All patients were evaluated for SUI and divided into two groups: 116 women with SUI and 76 women without SUI. Diagnosis of SUI was based on the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF). Levels of IGF-1 were measured in serum by enzyme-linked immunosorbent assay. The relationship between IGF-1 levels and SUI in patients was evaluated statisticaly. Results: The mean age of patients wiyh SUI was 49.9 +/- 8.6 and 48.7 +/- 7.8 in control group. Plasma IGF-1 levels were significantly lower in SUI than in control group (106.5 +/- 26.4 and 133.3 +/- 37.1ng/mL, respectively, P < 0.001). Body mass indexes were higher in women with SUI than women without SUI. Conclusion: In this study lower serum IGF-1 levels were found to be associated with SUI. Serum IGF-1 level appears to be a specific predictor of SUI, and it may be used in early prediction of SUI in female population.
dc.identifier.citationÖzbek, E., Ötünçtemur, A., Şahin, S., Özcan, L., Dursun, M., Polat, E. ... Çekmen, M. (2016). Low serum insulin like growth factor - 1 in patients with stress urinary incontinence. International Braz J Urol, 42(4), 787-792. https://dx.doi.org/10.1590/S1677-5538.IBJU.2015.0453
dc.identifier.doi10.1590/S1677-5538.IBJU.2015.0453
dc.identifier.endpage792
dc.identifier.issn1677-5538
dc.identifier.issn1677-6119
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage787
dc.identifier.urihttps://dx.doi.org/10.1590/S1677-5538.IBJU.2015.0453
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2724
dc.identifier.volume42
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBrazilian Soc Urol
dc.relation.ispartofInternational Braz J Urolen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectUrinary Incontinence, Stress
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectInsulin-Like Growth Factor I
dc.titleLow serum insulin like growth factor - 1 in patients with stress urinary incontinence
dc.typeArticle

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