The resolvin D1 levels before and after periodontal therapy in periodontitis patients

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dc.authorid0000-0001-5166-2109
dc.contributor.authorGökmenoğlu, Ceren
dc.contributor.authorTürkmen, Emrah
dc.contributor.authorÖngöz Dede, Figen
dc.contributor.authorErbak Yılmaz, Huriye
dc.contributor.authorCankat Kara, Mehmet
dc.contributor.authorÇanakçı, Varol
dc.date.accessioned2022-12-07T13:03:45Z
dc.date.available2022-12-07T13:03:45Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.description.abstractObjective The aim of this study was to determine the levels of resolvin D1 (RVD1) in the gingival crevicular fluid (GCF) and saliva in the patients with periodontitis and healthy subjects, and also to evaluate the effects of non-surgical periodontal treatments (NSPTs) on RVD1 levels. Materials and methods Fifteen patients with Stage III Grade B periodontitis (P) and 11 periodontally healthy individuals (H) were included in this study. Clinical periodontal measurements, GCF, and saliva samples were collected from each individual at baseline and 6 weeks after NSPTs in periodontitis group. GCF and saliva levels of RVD1 were analyzed by enzyme-linked immunosorbent assay. Results GCF total and concentration levels of RVD1 were significantly lower in the periodontitis group than in the healthy group and significantly increased after NSPTs in periodontitis (p < 0.001). There was no statistically significant difference in saliva RVD1 levels between healthy and periodontitis group and also before and after NSPTs in periodontitis (p > 0.05). Significant negative correlations were found between all periodontal clinical parameters and GCF volume with both GCF total amount and concentrations of RVD1 (p < 0.01). There was a positive correlation between GCF total amount and concentrations of RVD1 (r = 0.762, p < 0.01). Conclusions GCF levels of RVD1 might be promising biomarkers for monitoring the susceptibility to periodontitis and predicting periodontal status.
dc.identifier.citationGökmenoğlu, C., Türkmen, E., Öngöz Dede, F., Erbak Yılmaz, H., Cankat Kara, M. ve Çanakçı, V. (2022). The resolvin D1 levels before and after periodontal therapy in periodontitis patients. Clinical Oral Investigations, 26(10), 6379-6385. https://doi.org/10.1007/s00784-022-04593-9
dc.identifier.doi10.1007/s00784-022-04593-9
dc.identifier.endpage6385
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue10
dc.identifier.pmid35760881
dc.identifier.scopus2-s2.0-85132811431
dc.identifier.scopusqualityQ1
dc.identifier.startpage6379
dc.identifier.urihttps://doi.org/10.1007/s00784-022-04593-9
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10086
dc.identifier.volume26
dc.identifier.wos000817062300001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTürkmen, Emrah
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofClinical Oral Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGingival Crevicular Fluid
dc.subjectNon-Surgical Periodontal Treatment
dc.subjectPeriodontitis
dc.subjectResolvin D1
dc.subjectSaliva
dc.titleThe resolvin D1 levels before and after periodontal therapy in periodontitis patients
dc.typeArticle

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