Oral and gut microbial profiling in periodontitis and parkinson's disease

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dc.authorid0000-0001-7409-1484
dc.authorid0000-0001-7986-7085
dc.authorid0000-0002-8811-2263
dc.contributor.authorYay, Ekin
dc.contributor.authorYılmaz, Melis
dc.contributor.authorToygar, Hilal
dc.contributor.authorBalcı, Nur
dc.contributor.authorRivas, Carla Alvarez
dc.contributor.authorBolluk Kılıç, Başak
dc.contributor.authorZırh, Ali
dc.contributor.authorPaster, Bruce J.
dc.contributor.authorKantarcı, Alpdoğan
dc.date.accessioned2024-04-02T08:17:22Z
dc.date.available2024-04-02T08:17:22Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractObjectivesWe tested the hypothesis that Parkinson's disease (PA) alters the periodontitis-associated oral microbiome.MethodPatients with periodontitis with Parkinson's disease (PA+P) and without PA (P) and systemically and periodontally healthy individuals (HC) were enrolled. Clinical, periodontal and neurological parameters were recorded. The severity of PA motor functions was measured. Unstimulated saliva samples and stool samples were collected. Next-generation sequencing of 16S ribosomal RNA (V1-V3 regions) was performed.ResultsPA patients had mild-to-moderate motor dysfunction and comparable plaque scores as those without, indicating that oral hygiene was efficient in the PA+P group. In saliva, there were statistically significant differences in beta diversity between HC and PA+P (p = 0.001), HC and P (p = 0.001), and P and PA+P (p = 0.028). The microbial profiles of saliva and fecal samples were distinct. Mycoplasma faucium, Tannerella forsythia, Parvimonas micra, and Saccharibacteria (TM7) were increased in P; Prevotella pallens, Prevotella melaninogenica, Neisseria multispecies were more abundant in PA+P group, Ruthenibacterium lactatiformans, Dialister succinatiphilus, Butyrivibrio crossotus and Alloprevotella tannerae were detected in fecal samples in P groups compared to healthy controls.ConclusionsNo significant differences were detected between Parkinson's and non-Parkinson's gut microbiomes, suggesting that Parkinson's disease modifies the oral microbiome in periodontitis subjects independent of the gut microbiome.
dc.description.sponsorshipR01AG062496en_US
dc.identifier.citationYay, E., Yılmaz, M., Toygar, H., Balcı, N., Rivas, C. A., Bolluk Kılıç, B. ... Kantarcı, A. (2024). Oral and gut microbial profiling in periodontitis and parkinson's disease. Journal of Oral Microbiology, 16(1). https://dx.doi.org/10.1080/20002297.2024.2331264
dc.identifier.doi10.1080/20002297.2024.2331264
dc.identifier.issn2000-2297
dc.identifier.issue1
dc.identifier.pmid38528960
dc.identifier.scopus2-s2.0-85188475640
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1080/20002297.2024.2331264
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12410
dc.identifier.volume16
dc.identifier.wos001188911700001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Melis
dc.institutionauthorToygar, Hilal
dc.institutionauthorBalcı, Nur
dc.institutionauthorRivas, Carla Alvarez
dc.institutionauthorZırh, Ali
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Oral Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPeriodontitis
dc.subjectParkinson’s Disease
dc.subjectMicrobiome
dc.subjectNext- Generation Sequencing
dc.subjectPathogenesis
dc.titleOral and gut microbial profiling in periodontitis and parkinson's disease
dc.typeArticle

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