Adjusting the QRS duration by body mass index for prediction of response to cardiac resynchronization therapy: Does one QRS size fit all?

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dc.authorid0000-0002-4281-0867
dc.authorid0000-0003-2995-8792
dc.authorid0000-0003-0230-6575
dc.authorid0000-0003-2714-4584
dc.authorid0000-0001-5825-8627
dc.authorid0000-0002-4951-6716
dc.contributor.authorKaraca, Oğuz
dc.contributor.authorOmaygenç, Mehmet Onur
dc.contributor.authorÇakal, Beytullah
dc.contributor.authorÇakal Deniz, Sinem
dc.contributor.authorGüneş, Hacı Murat
dc.contributor.authorOlgun, Erkam
dc.contributor.authorİbişoğlu, Ersin
dc.contributor.authorSavur, Ümeyir
dc.contributor.authorGökdeniz, Tayyar
dc.contributor.authorBoztosun, Bilal
dc.contributor.authorKılıçaslan, Fethi
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:37:38Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:37:38Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractBackground: QRS duration (QRSd) is known to be affected by body weight and length. We tested the hypothesis that adjusting the QRSd by body mass index (BMI) may provide individualization for patient selection and improve prediction of cardiac resynchronization therapy (CRT) response. Methods: A total of 125 CRT recipients was analyzed to assess functional (?1 grade reduction in NYHA class) and echocardiographic (?15% reduction in LVESV) response to CRT at 6 months of implantation. Baseline QRSd was adjusted by BMI to create a QRS index (QRSd/BMI) and tested for prediction of CRT response in comparison to QRSd. Results: Overall, 81 patients (65%) responded to CRT volumetrically. The mean QRS index was higher in CRT responders compared to nonresponders (6.2 ± 1.1 vs 5.2 ± 0.8 ms.m2/kg, P < 0.001). There was a positive linear correlation between the QRS index and the change in LVESV (r = 0.487, P < 0.001). Patients with a high QRS index (?5.5 ms.m2/kg, derived from the ROC analysis, AUC = 0.787) compared to those with a prolonged QRSd (?150 ms, AUC = 0.729) had a greater functional (72% vs 28%, P < 0.001) and echocardiographic (80% vs 44%, P < 0.001) improvement at 6 months. QRS index predicted CRT response at regression analysis. Conclusions: Indexing the QRSd by BMI improves patient selection for CRT by eliminating the influence of body weight and length on QRSd. QRS index is a novel indicator that provides promising results for prediction of CRT response.
dc.identifier.citationKaraca, O., Omaygenç, M. O., Çakal, B., Çakal Deniz, S., Güneş, H. M., Olgun, E. ... Kılıçaslan, F. (2016). Adjusting the QRS duration by body mass index for prediction of response to cardiac resynchronization therapy: Does one QRS size fit all? Annals of Noninvasive Electrocardiology, 21(5), 450-459. https://dx.doi.org/10.1111/anec.12346
dc.identifier.doi10.1111/anec.12346
dc.identifier.endpage459
dc.identifier.issn1082-720X
dc.identifier.issue5
dc.identifier.scopusqualityQ2
dc.identifier.startpage450
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1442
dc.identifier.urihttps://dx.doi.org/10.1111/anec.12346
dc.identifier.volume21
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAnnals of Noninvasive Electrocardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCardiac Resynchronization Therapy
dc.subjectCRT Response
dc.subjectQRS Duration
dc.subjectQRS Index
dc.titleAdjusting the QRS duration by body mass index for prediction of response to cardiac resynchronization therapy: Does one QRS size fit all?
dc.typeArticle

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