Prognostic implications of response to neoadjuvant chemotherapy in breast cancer subtypes

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dc.authorid0000-0002-0443-6966
dc.authorid0000-0003-2715-4002
dc.authorid0000-0002-5823-1704
dc.authorid0000-0002-9452-9276
dc.authorid0000-0002-7685-2766
dc.authorid0000-0003-0128-6947
dc.authorid0000-0001-7934-7039
dc.contributor.authorYıldız, Anıl
dc.contributor.authorBilici, Ahmet
dc.contributor.authorAçıkgöz, Özgür
dc.contributor.authorHamdard, Jamshid
dc.contributor.authorBasım, Pelin
dc.contributor.authorÇakır, Tansel
dc.contributor.authorÇakır, Aslı
dc.contributor.authorÖlmez, Ömer Fatih
dc.contributor.authorGezen, Cem
dc.contributor.authorYıldız, Özcan
dc.date.accessioned2024-03-01T08:15:35Z
dc.date.available2024-03-01T08:15:35Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göğüs Cerrahisi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nükleer Tıp Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractThe current study was designed to assess the response to treatment, as well as clinical and survival outcomes, across different breast cancer subtypes in patients who underwent neoadjuvant chemotherapy (NAC). From 2014 to 2019, a total of 139 patients who were histologically confirmed to have breast cancer, underwent NAC, and subsequently received breast and axillary surgery, were retrospectively included in this study. The rates of pathological complete response (pCR) to NAC were significantly higher for HER2-positive and triple-negative subtypes than for luminal A and HER2-negative subtypes (p = 0.013). Multivariate analysis for disease-free survival (DFS) revealed that tumour grade and the presence of pCR were independent prognostic factors. The presence or absence of a pCR with NAC was an independent prognostic indicator in the multivariate analysis for overall survival (OS). Lastly, achieving a pCR was independently predicted by 18F-FDG PET/CT findings, the HER2-positive subtype, and the triple-negative subtype. Despite the inherent methodological limitations, our findings underscore the significance of identifying predictive markers to tailor NAC plans, with the aim of improving survival outcomes.
dc.description.sponsorshipLocal Ethics Committee at the Istanbul Medipol Universityen_US
dc.identifier.citationYıldız, A., Bilici, A., Açıkgöz, Ö., Hamdard, J., Basım, P., Çakır, T. ... Yıldız, Ö. (2024). Prognostic implications of response to neoadjuvant chemotherapy in breast cancer subtypes. Journal of Chemotherapy. https://dx.doi.org/10.1080/1120009X.2024.2314830
dc.identifier.doi10.1080/1120009X.2024.2314830
dc.identifier.issn1120-009X
dc.identifier.issn1973-9478
dc.identifier.pmid38351652
dc.identifier.scopus2-s2.0-85185122893
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://dx.doi.org/10.1080/1120009X.2024.2314830
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12333
dc.identifier.wos001162400500001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYıldız, Anıl
dc.institutionauthorBilici, Ahmet
dc.institutionauthorAçıkgöz, Özgür
dc.institutionauthorHamdard, Jamshid
dc.institutionauthorBasım, Pelin
dc.institutionauthorÇakır, Tansel
dc.institutionauthorÇakır, Aslı
dc.institutionauthorÖlmez, Ömer Fatih
dc.institutionauthorGezen, Cem
dc.institutionauthorYıldız, Özcan
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofJournal of Chemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBreast Cancer
dc.subjectNeoadjuvant Chemotherapy
dc.subjectPathological Response
dc.subject18FDG PET/CT
dc.subjectDisease-Free Survival
dc.subjectPrognostic Factor
dc.titlePrognostic implications of response to neoadjuvant chemotherapy in breast cancer subtypes
dc.typeArticle

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