Ozone therapy restores immune dysfunction in refractory idiopathic granulomatous mastitis as a novel potential therapeutic approach

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dc.contributor.authorCabıoğlu, Neslihan
dc.contributor.authorÇetin Aktaş, Esin
dc.contributor.authorEmiroğlu, Selman
dc.contributor.authorTükenmez, Mustafa
dc.contributor.authorÖzkurt, Enver
dc.contributor.authorMüslümanoğlu, Mahmut
dc.contributor.authorİğci, Abdullah
dc.contributor.authorÖzmen, Vahit
dc.contributor.authorDeniz, Günnur
dc.contributor.authorDinççağ, Ahmet Sait
dc.contributor.authorGüven, Yusuf İzzettin
dc.date.accessioned2023-01-05T10:34:05Z
dc.date.available2023-01-05T10:34:05Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sürekli Eğitim Merkezi (SEM)
dc.description.abstractImmunological dysfunction has been suggested to play a major role in the pathogenesis of idiopathic granulomatous mastitis (IGM). We recently showed that ozone therapy was effective in patients with steroid-resistant IGM. This study assessed alterations in intracellular cytokine expression patterns in different T-lymphocyte subsets after ozone therapy in refractory IGM. Peripheral blood T lymphocyte subsets (CD8(+), CD4(+), CD4(+)CD25(+) CD127(-)) were analyzed via flow-cytometry for intracellular cytokine expressions IFN-gamma, TNF-alpha, IL-10, and TGF-beta before and after completion of 4-month systemic ozone therapy. Ozone therapy significantly increased the CD4(+)IFN-gamma(+) (p = 0.032), CD4(+)TNF-alpha(+) (p = 0.028), and the CD8(+) TNF-alpha(+) (p =0.012) T cells. In contrast, significant decreases in CD4(+) IL-10(+) (p = 0.047) and CD8(+)IL-10(+) T cells (p = 0.022) and CD4(+)CD25(+) CD127(-//low) Treg cells secreting TGF-beta (p = 0.005) were found after ozone therapy. When patients were analyzed according to the response to ozone therapy, patients with a complete remission were more likely to have increased CD3(-)CD16(+)CD56(+) natural killer cells (p = 0.0027) and decreased CD19(+)B lymphocytes (p = 0.046) following ozone therapy. Our results suggest that ozone therapy stimulated a T-helper-1 response associated with IFN-gamma production and downregulation of TGF-beta expression in CD4(+)CD25(+)CD127(-) Treg cells. These alterations in the immune system following ozone therapy can improve wound healing and restore immune dysfunction in patients with refractory IGM.
dc.description.sponsorshipIstanbul Breast Societyen_US
dc.identifier.citationCabıoğlu, N., Çetin Aktaş, E., Emiroğlu, S., Tükenmez, M., Özkurt, E., Müslümanoğlu, M. ... Güven, Y. İ. (2023). Ozone therapy restores immune dysfunction in refractory idiopathic granulomatous mastitis as a novel potential therapeutic approach. Cell Biology International, 47(1), 228-237. https://dx.doi.org/10.1002/cbin.11953
dc.identifier.doi10.1002/cbin.11953
dc.identifier.endpage237
dc.identifier.issn1065-6995
dc.identifier.issn1095-8355
dc.identifier.issue1
dc.identifier.pmid36378588
dc.identifier.scopus2-s2.0-85142185442
dc.identifier.scopusqualityQ2
dc.identifier.startpage228
dc.identifier.urihttps://dx.doi.org/10.1002/cbin.11953
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10246
dc.identifier.volume47
dc.identifier.wos000883778000001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüven, Yusuf İzzettin
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofCell Biology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectIdiopathic Granulomatous Mastitis
dc.subjectIFN??
dc.subjectIL?10
dc.subjectOzone Therapy
dc.subjectTGF??
dc.subjectTNF??
dc.titleOzone therapy restores immune dysfunction in refractory idiopathic granulomatous mastitis as a novel potential therapeutic approach
dc.typeArticle

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