Testis-sparing surgery in adult patients with germ cell tumors: Systematic search of the literature and focused review

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dc.authorid0000-0003-0906-4417
dc.contributor.authorHeidenreich, Axel
dc.contributor.authorSeelemeyer, Felix
dc.contributor.authorAltay, Bülent
dc.contributor.authordel Pilar Laguna Pes, Maria
dc.date.accessioned2023-06-09T08:36:18Z
dc.date.available2023-06-09T08:36:18Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractTestis-sparing surgery (TSS) is a guideline-recommended treatment option for men with synchronous or metachronous bilateral testicular germ-cell tumor (GCT) or GCT in a solitary testicle. The tumor volume should not exceed 50% of the total testicular volume and serum concentrations of both testosterone and luteinizing hormone should be within the normal ranges. After tumor enucleation, patients should undergo adjuvant radiation of the testicle in case of germ cell neoplasia in situ. The local relapse rate is approximately 4% if TSS is performed properly. Physiological serum testosterone concentrations are achieved in more than 85% of patients, and approximately 50% of men with intact spermatogenesis can achieve paternity. The risk of systemic metastases is not increased by TSS. Patient summary: Testis-sparing surgery is the treatment of choice for men with testicular cancer in both testes or in men who have just one testis. In more than 85% of patients this approach results in maintenance of normal testosterone levels.
dc.identifier.citationHeidenreich, A., Seelemeyer, F., Altay, B. ve del Pilar Laguna Pes, M. (2023). Testis-sparing surgery in adult patients with germ cell tumors: Systematic search of the literature and focused review. European Urology Focus, 9(2), 244-247. https://doi.org/10.1016/j.euf.2022.11.0012405-4569
dc.identifier.doi10.1016/j.euf.2022.11.0012405-4569
dc.identifier.endpage247
dc.identifier.issn2405-4569
dc.identifier.issue2
dc.identifier.pmid36418210
dc.identifier.scopus2-s2.0-85142308823
dc.identifier.scopusqualityQ1
dc.identifier.startpage244
dc.identifier.urihttps://doi.org/10.1016/j.euf.2022.11.0012405-4569
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11055
dc.identifier.volume9
dc.identifier.wos000995010200001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthordel Pilar Laguna Pes, Maria
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofEuropean Urology Focusen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectSystematic Search
dc.subjectGerm Cell Tumors
dc.subjectAdult Patients
dc.titleTestis-sparing surgery in adult patients with germ cell tumors: Systematic search of the literature and focused review
dc.typeReview Article

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