Social isolation initiated post-weaning augments ischemic brain injury by promoting pro-inflammatory responses

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dc.authorid0000-0003-2251-2093
dc.authorid0000-0002-6242-3709
dc.authorid0000-0001-7266-9844
dc.authorid0000-0002-9476-8488
dc.authorid0000-0002-6637-9944
dc.contributor.authorDaşdelen, Muhammed Furkan
dc.contributor.authorÇağlayan, Ahmet Burak
dc.contributor.authorEr, Sezgin
dc.contributor.authorBeker, Mustafa Çağlar
dc.contributor.authorAteş, Nilay
dc.contributor.authorGronewold, Janine
dc.contributor.authorDoeppner, Thorsten Roland
dc.contributor.authorHermann, Dirk M.
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned2024-03-07T12:19:24Z
dc.date.available2024-03-07T12:19:24Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractSocial isolation is associated with poor stroke outcome, but the underlying molecular mechanisms were largely unknown. In male Balb/C mice exposed to transient middle cerebral artery occlusion (MCAo), we examined the effects of social isolation initiated post-weaning on ischemic injury, cytokine/chemokine responses and cell signaling using a broad panel of techniques that involved immunocytochemistry, cytokine/chemokine array and Western blots. Social isolation initiated post-weaning elevated infarct size, brain edema and neuronal injury in the ischemic brain tissue 3 days after MCAo, and increased microglia/ macrophage and leukocyte accumulation. In line with the increased immune cell recruitment, levels of several proinflammatory cytokines (e.g., IL-1?, IL-1?, IL-13, IL-17, TNF-?, IFN-?), chemokines (e.g., CCL3, CCL4, CCL12, CXCL2, CXCL9, CXCL12) and adhesion molecules (i.e., ICAM-1) were increased in the ischemic brain tissue of socially isolated compared with paired housing mice, whereas levels of selected cytokines (IL-5, IL-6, IL-16) and colony-stimulating factors (G-CSF, GM-CSF) were reduced. The activity of the transcription factor nuclear factor-?B (NF-?B), which promotes cell injury via pro-inflammatory responses, was increased by social isolation, whereas that of nuclear factor erythroid related factor-2 (Nrf-2), which mediates anti-oxidative responses under oxidative stress conditions, was reduced. Our study shows that social isolation profoundly alters post-ischemic cell signaling in a way promoting pro-inflammatory responses. Our results highlight the importance of social support in preventing deleterious health effects of social isolation.
dc.description.sponsorshipTUBAen_US
dc.identifier.citationDaşdelen, M. F., Çağlayan, A. B., Er, S., Beker, M. Ç., Ateş, N., Gronewold, J. ... Kılıç, E. (2024). Social isolation initiated post-weaning augments ischemic brain injury by promoting pro-inflammatory responses. Experimental Neurology, 375. https://dx.doi.org/10.1016/j.expneurol.2024.114729
dc.identifier.doi10.1016/j.expneurol.2024.114729
dc.identifier.issn0014-4886
dc.identifier.pmid38365135
dc.identifier.scopus2-s2.0-85185511954
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1016/j.expneurol.2024.114729
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12342
dc.identifier.volume375
dc.identifier.wosQ1en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDaşdelen, Muhammed Furkan
dc.institutionauthorÇağlayan, Ahmet Burak
dc.institutionauthorEr, Sezgin
dc.institutionauthorBeker, Mustafa Çağlar
dc.institutionauthorAteş, Nilay
dc.language.isoen
dc.publisherAcademic Press Inc.
dc.relation.ispartofExperimental Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectChemokine
dc.subjectCytokine
dc.subjectIschemic Stroke
dc.subjectLoneliness
dc.subjectMicroglia
dc.subjectNeuroinflammation
dc.titleSocial isolation initiated post-weaning augments ischemic brain injury by promoting pro-inflammatory responses
dc.typeArticle

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