Worldwide distribution, risk factors, and temporal trends of testicular cancer incidence and mortality: A global analysis

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dc.authorid0000-0003-0906-4417
dc.contributor.authorHuang, Junjie
dc.contributor.authorChan, Sze Chai
dc.contributor.authorTin, Man Sing
dc.contributor.authorLiu, Xianjing
dc.contributor.authorLok, Veeleah Ting-Ting
dc.contributor.authorNgai, Chun Ho
dc.contributor.authorZhang, Lin
dc.contributor.authorLucero-Prisno, Don Eliseo
dc.contributor.authorXu, Wanghong
dc.contributor.authorZheng, Zhi-Jie
dc.contributor.authorChiu, Peter Ka-Fung
dc.contributor.authorNg, Anthony Chi-Fai
dc.contributor.authorEnikeev, Dmitry
dc.contributor.authorNicol, David
dc.contributor.authorSpiess, Philippe E.
dc.contributor.authordel Pilar Laguna Pes, Maria
dc.contributor.authorTeoh, Jeremy Yuen-Chun
dc.contributor.authorWong, Martin C S
dc.date.accessioned2022-10-24T12:27:39Z
dc.date.available2022-10-24T12:27:39Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractBACKGROUND: Testicular cancer is a common malignancy among young males in western countries. OBJECTIVE: To examine the global disease burden and trends of testicular cancer incidence and mortality by age and country, and their associations with human development index (HDI), gross domestic product (GDP), lifestyle habits, and metabolic risk factors. DESIGN, SETTING, AND PARTICIPANTS: We retrieved the Global Cancer Observatory database for the testicular cancer incidence and mortality in 2020; the World Bank for GDP per capita; the United Nations for HDI; the WHO Global Health Observatory for prevalence of smoking and alcohol drinking; and the Cancer Incidence in Five Continents, WHO mortality database, Surveillance, Epidemiology, and End Results programme and Nordic Cancer Registries (NORDCAN) for trend analysis. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: We presented the testicular cancer incidence and mortality using age-standardised rates. We examined their associations with HDI, GDP, smoking, alcohol drinking, physical inactivity, overweight, obesity, and medical conditions including diabetes, hypertension, and hypercholesterolaemia by linear regression. We estimated the 10-yr trend of incidence and mortality by joinpoint regression with average annual percentage change with 95% confidence intervals in different age groups. RESULTS AND LIMITATIONS: There was a wide variation in the testicular cancer burden with the highest mortality found in low-income countries, and the regions of Central America and South America, while the highest incidence was observed in high-income countries, especially in Western and Northern Europe. We found a positive association for HDI, GDP, alcohol drinking, inactivity, overweight, obesity, and hypercholesterolaemia with testicular cancer incidence, while a negative correlation was observed between GDP and mortality of testicular cancer. Globally, there was an overall increasing incidence trend of testicular cancer for the past decade, particularly in younger males; the mortality trends of testicular cancer were relatively stable. However, we did not analyse the trend of different stages and subtypes of testicular cancer due to data unavailability. CONCLUSIONS: There was a global variation in the testicular cancer burden associated with HDI, GDP, alcohol drinking, inactivity, overweight, obesity, and hypercholesterolaemia. Testicular cancer had an increasing incidence but decreasing mortality. The increasing testicular cancer incidence in the younger population is of concern and calls for early detection and preventive interventions. PATIENT SUMMARY: Globally, testicular cancer incidence had been increasing particularly in the younger population, although its deaths rates had been decreasing. Socioeconomic indices, alcohol drinking, inactivity, overweight, obesity, and high plasma lipid levels are associated with testicular cancer incidence and mortality.
dc.identifier.citationHuang, J., Chan, S. C., Tin, M. S., Liu, X., Lok, V. T.-T., Ngai, C. H. ... Wong, M. C S (2022). Worldwide distribution, risk factors, and temporal trends of testicular cancer incidence and mortality: A global analysis. European Urology Oncology, 5(5), 566-576. https://doi.org/10.1016/j.euo.2022.06.009
dc.identifier.doi10.1016/j.euo.2022.06.009
dc.identifier.endpage576
dc.identifier.issn2588-9311
dc.identifier.issue5
dc.identifier.pmid35863988
dc.identifier.scopus2-s2.0-85139573122
dc.identifier.scopusqualityQ1
dc.identifier.startpage566
dc.identifier.urihttps://doi.org/10.1016/j.euo.2022.06.009
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9873
dc.identifier.volume5
dc.identifier.wos000883326800015en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthordel Pilar Laguna Pes, Maria
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofEuropean Urology Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAlcohol Drinking
dc.subjectIncidence
dc.subjectMortality
dc.subjectSmoking
dc.subjectTemporal Trend
dc.subjectTesticular Cancer
dc.titleWorldwide distribution, risk factors, and temporal trends of testicular cancer incidence and mortality: A global analysis
dc.typeArticle

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